Mouse Genome Modification

  • Richard Rozmahel
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 89)


The ability to alter the mouse genome through homologous recombination in their embryonic stem (ES) cells, and propagate the modification through their germ-line, has revolutionized biomedical research. Such gene-targeted mice have afforded researchers unprecedented opportunities to analyze gene function in vivo, and provided models for disease studies.


Embryonic Stem Cell Homologous Recombination Inducible System Embryonic Stem Cell Line Thymidine Kinase Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 2003

Authors and Affiliations

  • Richard Rozmahel
    • 1
  1. 1.Department of PharmacologyUniversity of TorontoTorontoCanada

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