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Oxygen Free Radicals in Heart Disease

Novel Therapies

  • Protocol
Cardiac Drug Development Guide

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

During evolutionary processes, the development of aerobic metabolism has led to the liberation of reactive oxygen species (ROS) in living creatures by leakage from terminal oxidation and other enzymatic processes even under physiological conditions. Free radicals have unpaired electrons on their outer orbit, which makes these short-lived molecular fragments highly reactive with biomolecules, such as lipids, proteins, nucleic acids, and carbohydrates. These reactions are self-perpetuating chain reactions, further increasing their destructive potential. Excessive amounts of free radicals can significantly impair cellular structure and function and even can induce different forms of cell death. The development of inheritable adaptation mechanisms against oxidative stress improved the survival of the individual and the species in general as a benefit of selection (1,2). The comprehensive role of ROS in intracellular signaling mechanisms during physiological circumstances has later been recognized (3). The formation, actions and inactivation of free radicals are summarized in Fig. 1.

The generation, detoxification, and biological effects of ROS

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Authors and Affiliations

  1. Department of Experimental Surgery, Medical Faculty, University of Pecs, Pecs, Hungary

    Elizabeth Roth

  2. Division of Cardiac Surgery, Heart Institute, Medical Faculty, University of Pecs, Pecs, Hungary

    Laszlo Hejjel

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  1. Elizabeth Roth
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  2. Laszlo Hejjel
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  1. Department of Pharmacology, Forest Research Institute, Jersey City, NJ

    Michael K. Pugsley

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© 2003 Humana Press Inc., Totowa, NJ

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Roth, E., Hejjel, L. (2003). Oxygen Free Radicals in Heart Disease. In: Pugsley, M.K. (eds) Cardiac Drug Development Guide. Methods in Pharmacology and Toxicology. Humana Press. https://doi.org/10.1385/1-59259-404-2:47

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  • DOI: https://doi.org/10.1385/1-59259-404-2:47

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-097-7

  • Online ISBN: 978-1-59259-404-7

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