Abstract
Variation coupled to selection is the hallmark of natural evolution. Although there is no full agreement concerning the best way to create variation, mutation or recombination (1), computational simulation studies have demonstrated the importance of homologous recombination in the evolution of biological systems (2,3). As compared to random mutagenesis, recombination may be advantageous in combining beneficial mutations that have arisen independently and may be synergistic, while simultaneously removing deleterious mutations.
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© 2003 Humana Press Inc., Totowa, NJ
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Esteban, O., Woodyer, R.D., Zhao, H. (2003). In Vitro DNA Recombination by Random Priming. In: Arnold, F.H., Georgiou, G. (eds) Directed Evolution Library Creation. Methods in Molecular Biology™, vol 231. Humana Press. https://doi.org/10.1385/1-59259-395-X:99
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DOI: https://doi.org/10.1385/1-59259-395-X:99
Publisher Name: Humana Press
Print ISBN: 978-1-58829-285-8
Online ISBN: 978-1-59259-395-8
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