Abstract
Immunohistochemistry (IHC) and similar techniques are the cornerstone of pathologic investigation to visualize and localize protein aggregates and inclusions found in the brains of individuals with neurodegenerative diseases. The principle of IHC is: use an antibody against a specific protein or sequence contained within a protein to demonstrate its presence within a section of tissue. IHC complements nicely traditional histopathologic staining such as Hematoxylin/Eosin and Silver stains and adds specificity to the identification of protein misfolding in neuromorphometric analysis.
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Galvin, J.E. (2003). Detection of Aggregates and Protein Inclusions by Staining of Tissues. In: Bross, P., Gregersen, N. (eds) Protein Misfolding and Disease. Methods in Molecular Biology™, vol 232. Humana Press. https://doi.org/10.1385/1-59259-394-1:149
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DOI: https://doi.org/10.1385/1-59259-394-1:149
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