Abstract
The prognosis of patients with advanced liver tumors is very poor, regardless of current treatment schedules based on surgery and/or chemotherapy. Anti-angiogenic therapy represents one of the most promising target-oriented therapeutic approaches. However, because of organ-specific differentiation of liver microvasculature (1), the use of non organ-specific models of angiogenesis may not be adequate for screening candidate anti-angiogenic compounds, and only a few preclinical models that are able to provide clinically relevant therapeutic options are available.
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Olaso, E., Vidal-Vanaclocha, F. (2003). Use of Tumor-Activated Hepatic Stellate Cell as a Target for the Preclinical Testing of Anti-Angiogenic Drugs Against Hepatic Tumor Development. In: Buolamwini, J.K., Adjei, A.A. (eds) Novel Anticancer Drug Protocols. Methods in Molecular Medicine, vol 85. Humana Press. https://doi.org/10.1385/1-59259-380-1:79
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DOI: https://doi.org/10.1385/1-59259-380-1:79
Publisher Name: Humana Press
Print ISBN: 978-0-89603-963-6
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