Inflammatory Response of Tumor-Activated Hepatic Sinusoidal Endothelium as a Target for the Screening of Metastasis Chemopreventive Drugs

  • Lorea Mendoza
  • Fernando Vidal-Vanaclocha
Part of the Methods in Molecular Medicine book series (MIMM, volume 85)


The pathogenesis of cancer dissemination and metastasis involves a cascade of interdependent events (1). These are regulated by complex host-tumor cell interaction mechanisms, such as cancer cell adhesion to endothelium and extracellular matrix, cancer cell migration and invasion through stromal barriers, and cancer-induced immune cell disfunction and neo-angiogenesis. Proinflammatory cytokine blockade inhibits cancer metastasis development under experimental conditions (2,3), suggesting that proinflammatory mediators regulate host-tumor cell interactions contributing to arrest and implantation of disseminated cancer cells in target organs.


Sinusoidal Cell Cancer Cell Adhesion Cell Adhesion Molecule Expression Disseminate Cancer Cell B16M Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 2003

Authors and Affiliations

  • Lorea Mendoza
    • 1
  • Fernando Vidal-Vanaclocha
    • 2
  1. 1.PharmaKine Ltd.Zamudio Technology ParkBizkaiaSpain
  2. 2.Department of Cell BiologyBasque Country University School of Medicine and DentistryLeioaSpain

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