Advertisement

Inflammatory Response of Tumor-Activated Hepatic Sinusoidal Endothelium as a Target for the Screening of Metastasis Chemopreventive Drugs

  • Lorea Mendoza
  • Fernando Vidal-Vanaclocha
Part of the Methods in Molecular Medicine book series (MIMM, volume 85)

Abstract

The pathogenesis of cancer dissemination and metastasis involves a cascade of interdependent events (1). These are regulated by complex host-tumor cell interaction mechanisms, such as cancer cell adhesion to endothelium and extracellular matrix, cancer cell migration and invasion through stromal barriers, and cancer-induced immune cell disfunction and neo-angiogenesis. Proinflammatory cytokine blockade inhibits cancer metastasis development under experimental conditions (2,3), suggesting that proinflammatory mediators regulate host-tumor cell interactions contributing to arrest and implantation of disseminated cancer cells in target organs.

Keywords

Sinusoidal Cell Cancer Cell Adhesion Cell Adhesion Molecule Expression Disseminate Cancer Cell B16M Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Fidler, I. J. (1989) Origin and biology of cancer metastasis. Cytometry 10, 673–680.PubMedCrossRefGoogle Scholar
  2. 2.
    Orosz, P., Echtenacher, B., Falk, W., Ruschoff, J., Weber, D., and Mannel, D. N. (1993) Enhancement of experimental metastasis by tumor necrosis factor. J. Exp. Med. 177, 1391–1398.PubMedCrossRefGoogle Scholar
  3. 3.
    Vidal-Vanaclocha, F., Amézaga, C., Asumendi, A., Kaplanski, G., and Dinarello, C. A. (1994) Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases. Cancer Res. 54, 2667–2672.PubMedGoogle Scholar
  4. 4.
    Lafrenie, R. M., Buchanan, M. R., and Orr, F. W. (1993) Adhesion molecules and their role in cancer metastasis. Cell Biophys. 23, 3–89.PubMedGoogle Scholar
  5. 5.
    Balkwill, F and Mantovani, A. (2001) Inflammation and cancer: back to Virchow? Lancet 357, 539–545.PubMedCrossRefGoogle Scholar
  6. 6.
    Martín-Padura, I., Mortarini, R., Lauri, D., et al. (1991) Heterogeneity in human melanoma cell adhesion to cytokine activated endothelial cells correlates with VLA-4 expression. Cancer Res. 51, 2239–2241.PubMedGoogle Scholar
  7. 7.
    Chirivi, R. G. S., Garofalo, A., Padura, I. M., Mantovani, A., and Giavazzi, R. (1993) Interleukin-1 receptor antagonist inhibits the augmentation of metastasis induced by interleukin-1 or lipopolysaccharide in a human melanoma/nude mouse model. Cancer Res. 53, 5051–5054.PubMedGoogle Scholar
  8. 8.
    Vidal-Vanaclocha, F., Fantuzzi, G., Mendoza, L., et al. (2000) IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. Proc. Natl. Acad. Sci. USA 97, 734–739.PubMedCrossRefGoogle Scholar
  9. 9.
    Chen, Z., Colon, I., Ortiz, N., et al. (1998) Effects of IL-1alpha, IL-1Ra and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines. Cancer Res. 58, 3668–3676.PubMedGoogle Scholar
  10. 10.
    Köck, A., Schwarz, T., Urbanski, Z., et al. (1989) Expression and release of interleukin-1 by different human melanoma lines. J. Natl. Cancer Inst. 81, 36–42.PubMedCrossRefGoogle Scholar
  11. 11.
    Dong, G., Chen, Z., Kato, T. and Van Waes, C. (1999) The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine aquamous cell carcinoma. Cancer Res. 59, 3495–3504.PubMedGoogle Scholar
  12. 12.
    Burrows, F. J., Haskard, D. O., Hart, I. R., et al. (1991) Influence of tumor-derived interleukin-1 on melanoma-endothelial cell interactions in vitro. Cancer Res. 51, 4768–4775.PubMedGoogle Scholar
  13. 13.
    Kaji, M., Ishikuro, H., Kishimoto, T., et al. (1995) E-selectin expression induced by pancreas-carcinoma-derived interleukin-1-alpha results in enhanced adhesion of pancreas-carcinoma cells to endothelial cells. Int. J. Cancer 60, 715–717.CrossRefGoogle Scholar
  14. 14.
    Khatib, A. M., Kontogiannea, M., Fallavolita, L., Jamison, B., Meterissian, S., and Brodt, P. (1999) Rapid induction of cytokine and E-selectin expression in the liver in response to metastatic tumor cells. Cancer Res. 59, 1356–1361.PubMedGoogle Scholar
  15. 15.
    Mendoza, L., Carrascal, T., De Luca, M., et al. (2001) Hydrogen peroxide mediates vascular cell adhesion molecule-1 expression from interleukin-18-activated hepatic sinusoidal endothelium: Implications for circulating cancer cell arrest in the murine liver. Hepatology 34, 298–310.PubMedCrossRefGoogle Scholar
  16. 16.
    Danen, E. H., Marcinkiewicz, C., Cornelissen, I. M., et al. (1998) The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells. Exp. Cell. Res. 238, 188–196.PubMedCrossRefGoogle Scholar
  17. 17.
    Sugarbaker, E. V., Weingrand, D. N. and Roseman, J. M. (1982) Observations on cancer metastasis in man, in Tumor Invasion and Metastasis (Liotta, L. A. and Hart, I. R., eds.), Vol Nijhoff: The Jague: 427–465.Google Scholar
  18. 18.
    Rubio, N., Martinez-Villacampa, M. and Blanco, J. (1998) Traffic to lymph nodes of PC-3 prostate tumor cells in nude mice visualized using the luciferase gene as a tumor cell marker. Lab. Invest. 78, 1315–1325.PubMedGoogle Scholar
  19. 19.
    Vidal-Vanaclocha, F., Rocha, M., Asumendi, A. and Barbera-Guillem, E. (1993) Isolation and enrichment of two sublobular compartment-specific endothelial cell subpopulations from liver sinusoids. Hepatology 18, 328–339.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc., Totowa, NJ 2003

Authors and Affiliations

  • Lorea Mendoza
    • 1
  • Fernando Vidal-Vanaclocha
    • 2
  1. 1.PharmaKine Ltd.Zamudio Technology ParkBizkaiaSpain
  2. 2.Department of Cell BiologyBasque Country University School of Medicine and DentistryLeioaSpain

Personalised recommendations