IκB Kinase and NF-κB Signaling in Response to Pro-Inflammatory Cytokines

  • Mireille Delhase
Part of the Methods in Molecular Biology book series (MIMB, volume 225)


Exposure to pro-inflammatory cytokines (TNFα and IL-1) results in activation of signaling cascades that lead to stimulation of activity of the transcription factors AP-1 and NF-κB and induction of genes that are controlled by these transcription factors. Such genes code for cytokines (TNFα, IL-1, IL-2, IL-6, and GM-CSF), chemokines, adhesion molecules, and enzymes (iNOS and X-2) that produce secondary inflammatory mediators (1).


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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Mireille Delhase
    • 1
  1. 1.University of California at San DiegoLa Jolla

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