Air-Pouch Models of Inflammation and Modifications for the Study of Granuloma-Mediated Cartilage Degradation

  • Paul Colville-Nash
  • Toby Lawrence
Part of the Methods in Molecular Biology book series (MIMB, volume 225)


Animal models are essential for the study of the pathophysiological basis of disease this particularly holds true for the study of inflammation and inflammatory disease. The inflammatory response in vivo involves multiple interactions between signaling pathways which have developed a high degree of redundancy and synergy. Although it is possible to dissect individual inflammatory events in detail with in vitro studies, the interactions involved in the inflammatory response in vivo are difficult to simulate in vitro. The complex etiology of inflammatory disease has led to the development of many different models of both acute and chronic inflammation that have distinct advantages and limitations (1).


Cartilage Destruction Trisodium Citrate Scalpel Blade Anhydrous Sodium Acetate Citric Acid Monohydrate 
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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Paul Colville-Nash
    • 1
  • Toby Lawrence
    • 1
  1. 1.The William Harvey Research InstituteLondonUK

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