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Production and Characterization of Antipeptide Kallikrein 4 Antibodies

Use of Computer Modeling to Design Peptides Specific to Kallikrein 4

  • Protocol
Prostate Cancer Methods and Protocols

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 81))

Abstract

To date, prostate-specific antigen (PSA) has proven to be the most useful tumor marker for prostate cancer (1–3). However, the PSA test does not discriminate well between men with benign disease and early prostate cancer, and it does not discriminate between aggressive and slow-growing cancers (4,5). Although a useful additional discriminator (5), the advent of free/total PSA assays has not significantly improved this outcome. Thus, an inability to make an early diagnosis has led to the increased burden of metastatic disease, and many patients are overtreated because clinically aggressive disease cannot be distinguished from clinically insignificant disease.

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Authors and Affiliations

  1. Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia

    Tracey J. Harvey, Ying Dong, Loan Bui, Russell Jarrott, Terry Walsh & Judith A. Clements

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  1. Tracey J. Harvey
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  2. Ying Dong
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  3. Loan Bui
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  4. Russell Jarrott
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  5. Terry Walsh
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  6. Judith A. Clements
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Editors and Affiliations

  1. Oncology Research Centre, Prince of Wales Hospital, Randwick, Australia

    Pamela J. Russell , Paul Jackson  & Elizabeth A. Kingsley ,  & 

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© 2003 Humana Press Inc.

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Harvey, T.J., Dong, Y., Bui, L., Jarrott, R., Walsh, T., Clements, J.A. (2003). Production and Characterization of Antipeptide Kallikrein 4 Antibodies. In: Russell, P.J., Jackson, P., Kingsley, E.A. (eds) Prostate Cancer Methods and Protocols. Methods in Molecular Medicine™, vol 81. Springer, Totowa, NJ. https://doi.org/10.1385/1-59259-372-0:241

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  • DOI: https://doi.org/10.1385/1-59259-372-0:241

  • Publisher Name: Springer, Totowa, NJ

  • Print ISBN: 978-0-89603-978-0

  • Online ISBN: 978-1-59259-372-9

  • eBook Packages: Springer Protocols

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