Effects of Fixation on Tissues

  • Elin Mortensen
  • Julie M. Brown
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 81)


The primary aim of tissue fixation is to preserve tissue in the long term, ideally without causing alterations in morphology or biochemical integrity. Optimal fixation should therefore inhibit autolysis while preserving enzyme activity and antigen reactivity. However, some of these requirements are mutually exclusive. For example, to stop autolysis, proteolytic enzymes must be inhibited (1). At present, it is not possible to find a fixation technique that fulfils all of these criteria.


Core Biopsy Benzoyl Peroxide Microwave Treatment Paraffin Embedding Ammonium Oxalate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Elin Mortensen
    • 1
  • Julie M. Brown
    • 2
  1. 1.Department of PathologyUniversity Hospital of North NorwayTromsoeNorway
  2. 2.Oncology Research CentrePrince of Wales HospitalRandwickAustralia

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