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Cancer Cytogenetics pp 59–71Cite as

Acute Lymphoblastic Leukemia

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 220))

Abstract

Unlike the situation in acute myeloid leukemia, in which there are at least eight morphological French-American-British (FAB) subtypes identified by the predominant cell cytology, in acute lymphoblastic leukemia (ALL), there are only three (1). Furthermore, for most practical purposes, FAB types L1 and L2 are almost indistinguishable. Of more importance than the morphology of the cells in ALL is the immunophenotype. Apart from identifying an entirely separate T-cell type of ALL, immunology is able to identify cells at various stages of B-cell lineage maturation, including pro-B, pre-pre-B, pre-B, common (cALL), and mature B stages. The last stage constitutes FAB type L3, which has a very close affinity with Burkitt lymphoma; these two disorders share identical cytogenetic abnormalities and both are now formally termed Burkitt cell lymphoma (BL).

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References

  1. Bennett J. M., Catovsky D., Daniel M. T., et al. (FAB Co-operative Group) (1981). The morphological classification of acute lymphoblastic leukemias: concordance amongst observers and clinical correlations. Br. J. Haematol. 47, 553–561

    Article  PubMed  CAS  Google Scholar 

  2. Secker-Walker L. M., Lawler S. D., and Hardisty R. M. (1978). Prognostic implications of chromosomal findings in acute lymphoblastic leukemia at diagnosis. Br. Med. J. 23, 237–244.

    Google Scholar 

  3. Gibbons B., MaCallum P., Watts E., et al. (1991) Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature. Leukemia 5, 738–743.

    PubMed  CAS  Google Scholar 

  4. Bloomfield C. D., Secker-Walker L. W., Goldman A. I., et al. (1989) Six-year follow-up of the significance of karyotype in acute lymphoblastic leukemia (The Sixth International Workshop on Chromosomes in Leukemia, London, 1987) Cancer Genet. Cytogenet. 40, 171–185.

    Article  PubMed  CAS  Google Scholar 

  5. Heerema, N. A., Sather, H. N., Sensel, M. G., et al. (2000) Prognostic impact of trisomies of chromosomes 10, 17 and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (>50 chromosomes). J. Clin. Oncol. 18, 1876–1887.

    PubMed  CAS  Google Scholar 

  6. Moorman A. V., Clark R., Farrell D. M., Hawkins J. M., Martineau M., and Secker-Walker L. M. (1995) Modelling chromosome gain in hyperdiploid ALL: a Leukemia Research Fund United Kingdom Cancer Cytogenetics Group Study. Blood 86, 771a, Abstr. 3073.

    Google Scholar 

  7. Heim S., Alimena G., Billstrom R., et al. (1987) Tetraploid karyotype (92,XXYY) in two patients with acute lymphoblastic leukemia. Cancer Genet. Cytogenet. 29, 129–133

    Article  PubMed  CAS  Google Scholar 

  8. Secker Walker L. M., Berger R., Fenaux P., et al. (1992) The prognostic significance of the balanced t(1;19) and unbalanced der(19)t(1;19) translocations in acute lymphoblastic leukemia. Leukemia 6, 363–369.

    Google Scholar 

  9. Chessells J. M., Swansbury G. J., Reeves B., Bailey C. C., and Richards S. M. (1997) Cytogenetics and prognosis in childhood lymphoblastic leukemia: results of MRC UKALL X. Br. J. Haematol. 99, 93–100.

    Article  Google Scholar 

  10. Johansson, B., Moorman, A. V., Haas, O. A., et al. (1998) Hematologic malignancies with t(4;11)(q21;q23)—a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. Leukemia 12, 779–787.

    Article  PubMed  CAS  Google Scholar 

  11. Hayashi Y., Raimondi S. C., Look A. T., et al. (1990) Abnormalities of the long arm of chromosome 6 in childhood acute lymphoblastic leukemia. Blood 76, 1626–1630.

    PubMed  CAS  Google Scholar 

  12. Secker-Walker L. M., Craig J. M., Hawkins J. M., and Hoffbrand A. V. (1991) Philadelphia-positive acute lymphoblastic leukemia in adults: age distribution, BCR breakpoint and prognostic significance. Leukemia 5, 196–199.

    PubMed  CAS  Google Scholar 

  13. Fletcher J. A., Lynch E. A., Kimball V. M., Donnelly, M., Tantravahi R., and Sallan S. E. (1991) Translocation (9;22) is associated with extremely poor prognosis in intensively treated children with acute lymphoblastic leukemia. Blood 77, 435–439.

    PubMed  CAS  Google Scholar 

  14. Heerema, N. A., Sather, H. N., Sensel, M. G., et al. (1999) Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: a report from the Children’s Cancer Group. Blood 94, 537–44.

    Google Scholar 

  15. Mahmoud H., Carroll A. J., Behm F., et al. (1992) The non-random dic(9;12) translocation in acute lymphoblastic leukemia is associated with B-progenitor phenotype and an excellent prognosis. Leukemia 6, 703–707.

    PubMed  CAS  Google Scholar 

  16. Huret, J-L., Dessen, P., and Bernheim, A. (2001) An atlas on chromosomes in hematological malignancies. Example: 11q23 and MLL. Leukemia 15, 987–989. (http://www.infobiogen.fr/services/chromcancer)

    Article  PubMed  CAS  Google Scholar 

  17. Swansbury G. J., Slater R., Bain B. J., Moorman A. V., and Secker-Walker L. M. (1998). Hematological malignancies with t(9;11)(p21–22;q23)—a laboratory and clinical study of 125 cases. Leukemia 12, 792–800

    Article  PubMed  CAS  Google Scholar 

  18. Moorman A. V., Hagemeier A., Charrin C., Rieder H., and Secker-Walker L. M. (1998) The translocations t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients. Leukemia 12, 805–810.

    Article  PubMed  CAS  Google Scholar 

  19. Shurtleff S. A., Buijs A., Behm F. G., et al. (1995). TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 9, 1985–1989

    PubMed  CAS  Google Scholar 

  20. Raynaud, S. D., Dastugue, N., Zoccola, D., Shurtleff, S. A., Mathew, S., and Raimondi, S. C. (1999) Cytogenetic abnormalities associated with the t(12;21): a collaborative study of 169 children with t(l2;21)-positive acute lymphoblastic leukemia. Leukemia 13, 1325–1330.

    Article  PubMed  CAS  Google Scholar 

  21. Dube I. D. and Greenberg M. L. (1986) Phenotypic heterogeneity in three cases of lymphoid malignancy with chromosomal translocations in 14q11. Cytogenet. Cell Genet. 41, 215–218.

    Article  PubMed  CAS  Google Scholar 

  22. Williams D. L., Harris A., Williams K. J., Brosius M. J., and Lemonds W. (1984) A direct bone marrow chromosome technique for acute lymphoblastic leukemia. Cancer Genet. Cytogenet. 13, 239–257.

    Article  PubMed  CAS  Google Scholar 

  23. Williams D. L., Raimondi S., Rivera G., George S., Berard C. W., and Murphy S. B. (1985) Presence of clonal chromosome abnormalities in virtually all cases of acute lymphoblastic leukemia. N. Engl. J. Med. 313, 640.

    PubMed  CAS  Google Scholar 

  24. Heerema, N. A., Sather, H. N., Sensel, M. G., et al. (1998) Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children’s Cancer Group. J. Clin. Oncol. 16, 1270–1278.

    PubMed  CAS  Google Scholar 

  25. Brodeur G. M., Dahl G. V., Williams D. L., Tipton R. E., and Kalwinsky D. K. (1980) Transient leukemoid reaction and trisomy 21 mosaicism in a phenotypically normal newborn. Blood 55, 69–73.

    Google Scholar 

  26. Zipursky A., Peeters M., and Poon A. (1987) Megakaryoblastic leukemia and Down’s syndrome—a review. Prog. Clin. Biol. Res. 246, 33–56.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Academic Haematology and Cytogenetics, The Royal Marsden NHS Trust, The Institute of Cancer Research, Surrey, UK

    John Swansbury

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  1. John Swansbury
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Editors and Affiliations

  1. The Royal Marsden NHS Trust, The Institute of Cancer Research, Sutton, Surrey, UK

    John Swansbury

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© 2003 Humana Press Inc.

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Swansbury, J. (2003). Acute Lymphoblastic Leukemia. In: Swansbury, J. (eds) Cancer Cytogenetics. Methods in Molecular Biology™, vol 220. Humana Press. https://doi.org/10.1385/1-59259-363-1:059

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  • DOI: https://doi.org/10.1385/1-59259-363-1:059

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-080-9

  • Online ISBN: 978-1-59259-363-7

  • eBook Packages: Springer Protocols

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