The Myeloid Disorders

Background
  • John Swansbury
Part of the Methods in Molecular Biology™ book series (MIMB, volume 220)

Abstract

Malignant myeloid disorders have broadly similar responses to cytogenetic techniques and many have similar chromosome abnormalities. Included are diseases that are frankly malignant, such as acute myeloid leukemia (AML), and some that may be regarded as premalignant, such as the myeloproliferative disorders (MPD). A proportion of the premalignant group may progress to acute leukemia but they are serious diseases in their own right, often difficult to treat, and may be fatal. They are all clonal disorders, that is, the bone marrow includes a population of cells ultimately derived from a single abnormal cell, which usually tends to expand and eventually suppress or replace the growth and development of normal blood cells. This group of disorders includes the following:
  • The myeloproliferative disorders (MPD)

  • The chronic myeloid leukemias (CML)

  • The myelodysplastic syndromes (MDS)

  • Aplastic anemia (AA)

  • Acute myeloid leukemia (AML)

The major clinical and cytogenetic features of the myeloid malignancies are summarized in the following subheadings.

Keywords

Phosphorus Depression Lithium Lymphoma Benzene 

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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • John Swansbury
    • 1
  1. 1.Academic Haematology and Cytogenetics, The Royal Marsden NHS TrustThe Institute of Cancer ResearchUK

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