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Intermediate Cognitive Phenotypes Associated with Schizophrenia

  • Protocol
Psychiatric Genetics

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 77))

Abstract

The search for intermediate phenotypes to inform genetic studies of psychiatric disorders is never as productive and exciting as in neuropsychological studies, particularly those of schizophrenia. A variety of cognitive impairments are frequently seen in patients with schizophrenia, and appear to be core features of this illness. In contrast, cognitive impairments seen in other psychiatric disorders, such as depression and mania, are state-related and may not be essential to these disorders (1). In studies of patients with schizophrenia, cognitive impairments do not appear to be caused simply by secondary factors associated with severe mental illness, such as poor cooperation or medications. They are present from an early stage of the illness and are stable over time, suggesting trait-like properties. Furthermore, emerging data suggest, but have not proven, that different profiles of impairment may be present in subgroups of patients. Another feature that makes these cognitive measures attractive targets for genetic studies is that they are closely related to clinical and functional outcome. Thus, the genes underlying cognitive phenotypes may be the most relevant to improving the quality of patients’ lives. Three domains of cognition are generally affected, including working memory/executive function, verbal/declarative memory, and attention.

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Author information

Authors and Affiliations

  1. Brain Disorders Branch, NIMH, Bethesda, MD, USA

    Michael F. Egan

  2. Brain Disorders Branch, NIMH, Bethesda, MD, USA

    Terry E. Goldberg

Authors
  1. Michael F. Egan
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  2. Terry E. Goldberg
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Editor information

Editors and Affiliations

  1. HĂ´pital Albert Chenevier, Creteil, France

    Marion Leboyer MD, PhD

  2. HĂ´pital Henri Mondor, Creteil, France

    Frank Bellivier MD, PhD

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© 2003 Humana Press Inc.

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Egan, M.F., Goldberg, T.E. (2003). Intermediate Cognitive Phenotypes Associated with Schizophrenia. In: Leboyer, M., Bellivier, F. (eds) Psychiatric Genetics. Methods in Molecular Medicine™, vol 77. Humana Press. https://doi.org/10.1385/1-59259-348-8:163

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  • DOI: https://doi.org/10.1385/1-59259-348-8:163

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-037-3

  • Online ISBN: 978-1-59259-348-4

  • eBook Packages: Springer Protocols

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