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Transgenic Mouse pp 333–361Cite as

Neuropathobiology in Transgenic Mice

The Case of Alzheimer’s Disease

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 209))

Abstract

The last decade has witnessed a quantum leap in our technical abilities to generate transgenic mice, up to the point that transgenic mouse models for any aspect of normal and pathologic physiology are within reach. Most difficult to attain, and impossible in humans, are invasive approaches in vivo, to define the molecular, biochemical and cellular functioning of the adult central nervous system (CNS) in normal conditions. However, even more desired, at least by some, are animal models for those neurodegenerative diseases that become increasingly devastating in the elderly. The most evident case in point is Alzheimer’s disease (AD).

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Authors
  1. Jo Van Dorpe
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  2. Kurt Spittaels
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  3. Chris Van den Haute
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  4. Ilse Dewachter
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  5. Dieder Moechars
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  6. Hugo Geerts
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  7. Fred Van Leuven
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Editor information

Editors and Affiliations

  1. Department of Molecular Genetics, University of Maastricht, Maastricht, The Netherlands

    Marten H. Hofker

  2. Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, MN

    Jan van Deursen

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© 2003 Humana Press Inc.

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Cite this protocol

Van Dorpe, J. et al. (2003). Neuropathobiology in Transgenic Mice. In: Hofker, M.H., van Deursen, J. (eds) Transgenic Mouse. Methods in Molecular Biology™, vol 209. Humana Press. https://doi.org/10.1385/1-59259-340-2:333

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  • DOI: https://doi.org/10.1385/1-59259-340-2:333

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-915-5

  • Online ISBN: 978-1-59259-340-8

  • eBook Packages: Springer Protocols

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