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Tailoring Kinetics of Antibodies Using Focused Combinatorial Libraries

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Recombinant Antibodies for Cancer Therapy

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 207))

Abstract

Antibodies have been used extensively for diagnostic applications for decades. Antibodies also can be used to target specific cells or specific molecules to produce agonist, antagonist, or neutralizing activity. Antibody therapies have been applied successfully in the treatment of several human diseases (1). The advantages of antibodies over other molecules are that they have high affinity for their targets and they bind to targets with high specificity. Antibodies, with six highly diversified complementaritydetermining regions (CDRs) supported by stable β-sheet framework regions, are capable of binding virtually any molecule including proteins, carbohydrates, nucleic acids, and haptens. The intrinsic features of specificity and affinity when combined offer a great advantage in the discovery of a wide-range of lead drug candidates.

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Authors and Affiliations

  1. MedImmune Inc., Gaithersburg, MD

    Herren Wu & Ling-Ling An

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  1. Herren Wu
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  2. Ling-Ling An
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Editors and Affiliations

  1. Axaron Bioscience AG, Heidelberg, Germany

    Martin Welschof

  2. National Institutes of Health, National Cancer Institute, Frederick, MD

    Jürgen Krauss

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© 2003 Humana Press Inc.

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Wu, H., An, LL. (2003). Tailoring Kinetics of Antibodies Using Focused Combinatorial Libraries. In: Welschof, M., Krauss, J. (eds) Recombinant Antibodies for Cancer Therapy. Methods in Molecular Biology™, vol 207. Humana Press. https://doi.org/10.1385/1-59259-334-8:213

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  • DOI: https://doi.org/10.1385/1-59259-334-8:213

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-918-6

  • Online ISBN: 978-1-59259-334-7

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