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Regulation of NF-κB by Oncoproteins and Tumor Suppressor Proteins

  • Protocol
Tumor Suppressor Genes

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 223))

Abstract

The transcription factor nuclear factor-κB (NF-κB) has been demonstrated to control cellular proliferation and oncogenesis. Consistent with this, NF-κB activity is stimulated by various mitogenic stimuli and by the action of numerous oncoproteins. This role of NF-κB in controlling oncogenesis is highlighted by observations that many oncoprotein signaling networks lead to the activation of NF-κB and that NF-κB is required for onco-gene-induced cellular transformation (1). Furthermore, it has also been demonstrated that various tumor suppressor gene products can function to negatively regulate NF-κB activity. However, evidence has been provided that NF-κB activity is required for the ability of p53 to induce cell death and that NF-κB can regulate p53 gene expression. This review highlights the complex roles that NF-κB subunits play in cellular transformation and analyzes mechanisms of oncoprotein-induced activation and tumor suppressor gene regulation of NF-κB. What is clear is that the role of NF-κB in regulating oncogenic mechanisms is complex, due to stimulus-specific, cell type-specific, or subunit-specific responses.

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Author information

Authors and Affiliations

  1. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC

    Lee V. Madrid & Albert S. Baldwin Jr.

Authors
  1. Lee V. Madrid
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  2. Albert S. Baldwin Jr.
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  2. Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  3. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

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© 2003 Humana Press Inc.

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Madrid, L.V., Baldwin, A.S. (2003). Regulation of NF-κB by Oncoproteins and Tumor Suppressor Proteins. In: El-Deiry, W.S. (eds) Tumor Suppressor Genes. Methods in Molecular Biology™, vol 223. Humana Press. https://doi.org/10.1385/1-59259-329-1:523

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  • DOI: https://doi.org/10.1385/1-59259-329-1:523

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-987-2

  • Online ISBN: 978-1-59259-329-3

  • eBook Packages: Springer Protocols

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