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Tumor Suppressor Genes pp 155–171Cite as

Analysis of Tumor Suppressor Gene-Induced Senescence

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 223))

Abstract

Cellular senescence refers to the response of cells to a variety of stimuli, many of which have the potential to induce preneoplastic or neoplastic phenotypes. These stimuli include dysfunctional telomeres, DNA damage, disrupted chromatin structures, the expression of certain oncogenes, and supraphysiologic mitogenic signals. The most prominent outcome of the senescence response is an essentially irreversible arrest of cell proliferation. In addition, senescent cells acquire marked changes in cell morphology and function. In some cases, senescent cells also acquire resistance to certain signals that induce apoptotic cell death (1–4).

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Authors and Affiliations

  1. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA

    Judith Campisi

  2. Buck Institute for Age Research, Novato, CA

    Judith Campisi

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  1. Judith Campisi
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  1. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  2. Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  3. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

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Campisi, J. (2003). Analysis of Tumor Suppressor Gene-Induced Senescence. In: El-Deiry, W.S. (eds) Tumor Suppressor Genes. Methods in Molecular Biology™, vol 223. Humana Press. https://doi.org/10.1385/1-59259-329-1:155

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  • DOI: https://doi.org/10.1385/1-59259-329-1:155

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