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The Regulation of Tumor Suppressor Genes by Oncogenes

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Tumor Suppressor Genes

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 222))

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Abstract

Tumor suppressor genes (TSGs) and oncogenes represent the ying and the yang of cell growth, differentiation, and survival control. TSGs such as p53, the retinoblastoma (RB) gene product, and the cyclin kinase inhibitor (CKI) proteins p21 Cip-1/WAF1/mda6 (p21), p27 Kip-1 (p27), p16 INK4a (p16), and p19 ARF (p19), play the role of negative regulators of the cell cycle (1–5). In contrast, mutation of protooncogenes such as the epidermal growth factor receptor (EGFR) (6), ErbB2 (Neu) (7), Ras (8,9), Raf-1 (10), PTEN (11,12), MKP-1 (13), and c-Myc (14) can promote cell cycle progression, in part by abrogating the negative regulation of the cell cycle by tumor suppressor genes.

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Authors and Affiliations

  1. Department of Radiation Oncology, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA

    Paul Dent, Liang Qiao & Donna Gilfor

  2. Biomarkers Branch, Division of Clinical Sciences, National Cancer Institute, Rockville, MD

    Michael Birrer

  3. Department of Medicine/Hematology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA

    Steven Grant

  4. Department of Urology and Pathology, College of Physicians and Surgeons, Columbia University, New York, NY

    Paul B. Fisher

Authors
  1. Paul Dent
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  2. Liang Qiao
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  3. Donna Gilfor
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  4. Michael Birrer
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  5. Steven Grant
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  6. Paul B. Fisher
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Editor information

Editors and Affiliations

  1. Departments of Medicine, Genetics, and Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

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© 2003 Humana Press Inc.

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Dent, P., Qiao, L., Gilfor, D., Birrer, M., Grant, S., Fisher, P.B. (2003). The Regulation of Tumor Suppressor Genes by Oncogenes. In: El-Deiry, W.S. (eds) Tumor Suppressor Genes. Methods in Molecular Biology™, vol 222. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-328-3:269

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  • DOI: https://doi.org/10.1385/1-59259-328-3:269

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-986-5

  • Online ISBN: 978-1-59259-328-6

  • eBook Packages: Springer Protocols

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