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Detection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCT

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Lung Cancer

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 75))

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Abstract

Lung cancer is a disease with high incidence and mortality (1). The prognosis for patients with lung cancer is most favorable when tumors are detected early in a surgically resectable stage of non-small cell lung cancer (NSCLC). Methods that can increase the percentage of cases of lung cancer detected in early stage may theoretically lead to a decrease in mortality. However, in the past, screening programs for early detection of lung cancer that used chest X-ray of the thorax with or without sputum cytology have not been successful in reducing the high numbers of lung cancer deaths (2–5). Therefore, new approaches that use genetic alterations as potential biomarkers may be beneficial for early detection.

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Author information

Authors and Affiliations

  1. Department of Pathology, Maastricht University Hospital, Maastricht, The Netherlands

    Veerle A. M. C. Somers

  2. Department of Pathology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

    Frederick B. J. M. Thunnissen

Authors
  1. Veerle A. M. C. Somers
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  2. Frederick B. J. M. Thunnissen
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Editor information

Editors and Affiliations

  1. Children#x2019;s Hospital, Los Angeles, CA

    Barbara Driscoll phd

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© 2003 Humana Press Inc., Totowa, NJ

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Somers, V.A.M.C., Thunnissen, F.B.J.M. (2003). Detection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCT. In: Driscoll, B. (eds) Lung Cancer. Methods in Molecular Medicine™, vol 75. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-324-0:305

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  • DOI: https://doi.org/10.1385/1-59259-324-0:305

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-920-9

  • Online ISBN: 978-1-59259-324-8

  • eBook Packages: Springer Protocols

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