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Clinical and Biological Relevance of Recently Defined Categories of Pulmonary Neoplasia

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Lung Cancer

Part of the book series: Methods in Molecular Medicineā„¢ ((MIMM,volume 74))

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Abstract

The clinical management of lung neoplasia now involves considerations of several diagnostic categories that were not in common use only a few years ago. In particular, there is now an increased recognition of neuroendocrine differentiation in lung cancer, including acknowledgment of large-cell neuroendocrine cancer as a distinct class of lung cancer. In addition, there is growing awareness of various form of early neoplasia in the lung, particularly in situ squamous cell proliferations and atypical adenomatous proliferations. With an emphasis on implications for clinical management, this review will discuss the biology of these important categories of lung neoplasia and compare them to other commonly recognized forms of lung tumors.

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References

  1. Colby, T. V., and Travis, W. D. (1995) Small cell carcinoma and large cell neuroendocrine carcinoma, in Atlas of Tumor Pathology, Third Series: Tumors of the Lower Respiratory Tract (Colby, T. V., K., M. N., and Travis, W. D., eds.), Armed Forces Institute of Pathology, Washington, DC, pp. 235ā€“257.

    Google ScholarĀ 

  2. Mackay, B., Ordonez, N. G., Bennington, J. L., and Dugan, C. C. (1989) Ultrastructural and morphometric features of poorly differentiated and undifferentiated lung tumors. Ultrastruct. Pathol. 13, 561ā€“571.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  3. Nomori, H., Shimosato, Y., Kodama, T., Morinaga, S., Nakajima, T., and Watanabe, S. (1986) Subtypes of small cell carcinoma of the lung: morphometric, ultrastructural, and immunohistochemical analyses. Hum. Pathol. 17, 604ā€“613.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  4. Guinee, D. G., Jr., Fishback, N. F., Koss, M. N., Abbondanzo, S. L., and Travis, W. D. (1994) The spectrum of immunohistochemical staining of small-cell lung carcinoma in specimens from transbronchial and open-lung biopsies. Am. J. Clin. Pathol. 102, 406ā€“414.

    PubMedĀ  Google ScholarĀ 

  5. Tabatowski, K., Vollmer, R. T., Tello, J. W., Iglehart, J. D., Shelburne, J. D., Schlom, J., and Johnston, W. W. (1988) The use of a panel of monoclonal antibodies in ultrastructurally characterized small cell carcinomas of the lung. Acta Cytol. 32, 667ā€“674.

    PubMedĀ  CASĀ  Google ScholarĀ 

  6. Colby, T. V. and Travis, W. D. (1995) Carcinoid and other neuroendocrine tumors, In Atlas of Tumor Pathology, Third Series: Tumors of the Lower Respiratory Tract (Colby, T. V. and Travis, W. D., eds.), Armed Forces Institute of Pathology, Washington, DC, pp. 287ā€“318

    Google ScholarĀ 

  7. Arrigoni, M. G., Woolner, L. B., and Bernatz, P. E. (1972) Atypical carcinoid tumors of the lung. J. Thorac. Cardiovasc. Surg. 64, 413ā€“421.

    PubMedĀ  CASĀ  Google ScholarĀ 

  8. Travis, W. D., Rush, W., Flieder, D. B., Falk, R., Fleming, M. V., Gal, A. A., and Koss, M. N. (1998) Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid. Am. J. Surg. Pathol. 22, 934ā€“944.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  9. Beasley, M. B., Thunnissen, F. B., Brambilla, E., Hasleton, P., Steele, R., Hammar, S. P., et al. (2000) Pulmonary atypical carcinoid: predictors of survival in 106 cases. Hum. Pathol. 31, 1255ā€“1265.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  10. Wilkins, E. W., Jr., Grillo, H. C., Moncure, A. C., and Scannell, J. G. (1984) Changing times in surgical management of bronchopulmonary carcinoid tumor. Ann. Thorac. Surg. 38, 339ā€“344.

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  11. Cutz, E. (1982) Neuroendocrine cells of the lung. An overview of morphologic characteristics and development. Exp. Lung Res. 3, 185ā€“208.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  12. Travis, W. D., Linnoila, R. I., Tsokos, M. G., Hitchcock, C. L., Cutler, G. B., Jr., Nieman, L., et al. (1991) Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohisto chemical, and flow cytometric study of 35 cases. Am. J. Surg. Pathol. 15, 529ā€“553.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  13. Flieder, D. B. and Vazquez, M. F (2000) Lung tumors with neuroendocrine morphology. A perspective for the new millennium. Radiol. Clin. North Am. 38, 563ā€“577, ix.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  14. Travis, W. D., Gal, A. A., Colby, T. V., Klimstra, D. S., Falk, R., and Koss, M. N. (1998) Reproducibility of neuroendocrine lung tumor classification. Hum. Pathol. 29, 272ā€“279.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  15. Linnoila, R. I., Piantadosi, S., and Ruckdeschel, J. C. (1994) Impact of neuroen-docrine differentiation in non-small cell lung cancer. The LCSG experience. Chest 106, 367Sā€“371S.

    PubMedĀ  CASĀ  Google ScholarĀ 

  16. Onuki, N., Wistuba, I. I., Travis, W. D., Virmani, A. K., Yashima, K., Brambilla, E., et al. (1999) Genetic changes in the spectrum of neuroendocrine lung tumors. Cancer 85 600ā€“607.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  17. Debelenko, L. V., Brambilla, E., Agarwal, S. K., Swalwell, J. I., Kester, M. B., Lubensky, I. A., et al. (1997) Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Hum. Mol. Genet. 6, 2285ā€“2290.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  18. Debelenko, L. V., Swalwell, J. I., Kelley, M. J., Brambilla, E., Manickam, P., Baibakov, G., et al. (2000) MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma. Genes Chromosomes Cancer 28, 58ā€“65.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  19. Anbazhagan, R., Tihan, T., Bornman, D. M., Johnston, J. C., Saltz, J. H., Weigering, A., et al. (1999) Classification of small cell lung cancer and pulmonary carcinoid by gene expression profiles. Cancer Res. 59, 5119ā€“5122.

    PubMedĀ  CASĀ  Google ScholarĀ 

  20. Ball, D. W., Azzoli, C. G., Baylin, S. B., Chi, D., Dou, S., Donis-Keller, H., et al. (1993) Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. Proc. Natl. Acad. Sci. USA 90, 5648ā€“5652.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  21. Auerbach, O., Hammond, E. C., and Garfinkel, L. (1979) Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977. N. Engl. J.Med. 300, 381ā€“385.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  22. Wistuba, I. I., Behrens, C., Milchgrub, S., Bryant, D., Hung, J., Minna, J. D., and Gazdar, A. F. (1999) Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma. Oncogene 18, 643ā€“650.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  23. Lam, S., Kennedy, T., Unger, M., Miller, Y. E., Gelmont, D., Rusch, V., et al. (1998) Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest 113, 696ā€“702.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  24. The Alpha-Tocopheral, B.-C.C.P.S.G. (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N. Engl. J. Med. 330, 1029ā€“1035.

    ArticleĀ  Google ScholarĀ 

  25. Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., et al. (1996) Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J. Natl. Cancer Inst. 88, 1550ā€“1559.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  26. Miller, R. R., Nelems, B., Evans, K. G., Muller, N. L., and Ostrow, D. N. (1988) Glandular neoplasia of the lung. A proposed analogy to colonic tumors. Cancer 61, 1009ā€“1014.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  27. Rao, S. K. and Fraire, A. E. (1995) Alveolar cell hyperplasia in association with adenocarcinoma of lung. Mod. Pathol. 8, 165ā€“169.

    PubMedĀ  CASĀ  Google ScholarĀ 

  28. Sterner, D. J., Mori, M., Roggli, V. L., and Fraire, A. E. (1997) Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases. Mod. Pathol. 10, 469ā€“473.

    PubMedĀ  CASĀ  Google ScholarĀ 

  29. Westra, W. H., Baas, I. O., Hruban, R. H., Askin, F. B., Wilson, K., Offerhaus, G. J., and Slebos, R. J. (1996) K-ras oncogene activation in atypical alveolar hyperplasias of the human lung. Cancer Res. 56 2224ā€“2228.

    PubMedĀ  CASĀ  Google ScholarĀ 

  30. Kitaguchi, S., Takeshima, Y., Nishisaka, T., and Inai, K. (1998) Proliferative activity, p53 expression and loss of heterozygosity on 3p, 9p and 17p in atypical adenomatous hyperplasia of the lung. Hiroshima J. Med. Sci. 47, 17ā€“25.

    PubMedĀ  CASĀ  Google ScholarĀ 

  31. Yashima, K., Litzky, L. A., Kaiser, L., Rogers, T., Lam, S., Wistuba, I. I., et al. (1997) Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas. Cancer Res. 57 2373ā€“2377.

    PubMedĀ  CASĀ  Google ScholarĀ 

  32. Suzuki, K., Nagai, K., Yoshida, J., Yokose, T., Kodama, T., Takahashi, K., et al. (1997) The prognosis of resected lung carcinoma associated with atypical adenomatous hyperplasia: a comparison of the prognosis of well-differentiated adenocarcinoma associated with atypical adenomatous hyperplasia and intrapulmonary metastasis. Cancer 79, 1521ā€“1526.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  33. Takigawa, N., Segawa, Y., Nakata, M., Saeki, H., Mandai, K., Kishino, D., et al. (1999) Clinical investigation of atypical adenomatous hyperplasia of the lung. Lung Cancer 25, 115ā€“121.

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

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Ā© 2003 Humana Press Inc., Totowa, NJ

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Gabrielson, E. (2003). Clinical and Biological Relevance of Recently Defined Categories of Pulmonary Neoplasia. In: Driscoll, B. (eds) Lung Cancer. Methods in Molecular Medicineā„¢, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-323-2:31

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  • DOI: https://doi.org/10.1385/1-59259-323-2:31

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-985-8

  • Online ISBN: 978-1-59259-323-1

  • eBook Packages: Springer Protocols

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