Abstract
Angiogenesis—the development and formation of new blood vessels—is important in a variety of processes such as growth and differentiation, wound healing, and the formation of neoplasms. An avascular tumor grows to a size of 2-3 mm and only rapidly expands when it becomes vascularized. Many cells, including tumor cells, affect the formation of new vessels by secreting angiogenic and anti-angiogenic factors (1). The balance of positive and negative angiogenic factors determines whether cells remain in a state of vascular homeostasis, or whether they proceed to the stage of neovascularization. These factors may include a combination of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived endothelial cell growth factor (PD-ECGF), and/or angiostatin.
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© 2003 Humana Press Inc., Totowa, NJ
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Volm, M., Koomägi, R. (2003). Prognostic Relevance of Angiogenic, Proliferative, and Apoptotic Factors in Lung Carcinomas. In: Driscoll, B. (eds) Lung Cancer. Methods in Molecular Medicine™, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-323-2:269
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DOI: https://doi.org/10.1385/1-59259-323-2:269
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-0-89603-985-8
Online ISBN: 978-1-59259-323-1
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