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Lung Cancer pp 167–186Cite as

Alterations in the Expression of Insulin-Like Growth Factors and Their Binding Proteins in Lung Cancer

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Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 74))

Abstract

The insulin-like growth factors (IGF), named for their structural homology to proinsulin, are potent mitogens involved in the endocrine, paracrine, and autocrine regulation of growth. IGF bioactivity may be altered by changes to any level of the IGF axis. The IGF axis is comprised of IGF-I and IGF-II, two IGF receptors, six IGF binding proteins (IGFBPs), and at least nine IGFBPrelated proteins (IGFBP-rPs).

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Author information

Authors and Affiliations

  1. Division of Endocrinology and Diabetes, The Children’ s Hospital of Philadelphia, Philadelphia, PA

    Carrie M. Coleman

  2. The Joseph Stokes, Jr. Research Institute of the Children’ s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA

    Adda Grimberg

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  1. Carrie M. Coleman
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  2. Adda Grimberg
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Editors and Affiliations

  1. Children’s Hospital, Los Angeles, CA, USA

    Barbara Driscoll PhD

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© 2003 Humana Press Inc., Totowa, NJ

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Coleman, C.M., Grimberg, A. (2003). Alterations in the Expression of Insulin-Like Growth Factors and Their Binding Proteins in Lung Cancer. In: Driscoll, B. (eds) Lung Cancer. Methods in Molecular Medicine™, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-323-2:167

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  • DOI: https://doi.org/10.1385/1-59259-323-2:167

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-985-8

  • Online ISBN: 978-1-59259-323-1

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