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Interaction of Shiga Toxin with Endothelial Cells

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E. coli

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 73))

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Abstract

The vascular endothelium was initially viewed as a “semipermeable” barrier between circulating blood and the interstitium and organ parenchyma. It is now evident that the endothelium plays a much more complex and active physiological and pathophysiological role. For example, endothelial cells regulate vascular tone by the release of vasoactive mediators, such as nitric oxide and endothelin, and orchestrate the response to inflammatory stimuli by the expression of vascular adhesion molecules and increased “leakiness” to circulating cells and proteins.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC

    Martin Bitzan

  2. Department of Pediatrics, University Medical Centre St. Radboud, Nijmegen, The Netherlands

    D. Maroeska W. M. te Loo

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  1. Martin Bitzan
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  2. D. Maroeska W. M. te Loo
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Editor information

Editors and Affiliations

  1. Groupe d&'Immunité Innée et Signalisation, Institut Pasteur, Paris, France

    Dana Philpott

  2. Max-von-Pettenkofer-Institut, Bakteriologie, Munich, Germany

    Frank Ebel

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© 2003 Humana Press Inc.

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Bitzan, M., Maroeska W. M. te Loo, D. (2003). Interaction of Shiga Toxin with Endothelial Cells. In: Philpott, D., Ebel, F. (eds) E. coli. Methods in Molecular Medicine™, vol 73. Humana Press. https://doi.org/10.1385/1-59259-316-X:243

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  • DOI: https://doi.org/10.1385/1-59259-316-X:243

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-939-1

  • Online ISBN: 978-1-59259-316-3

  • eBook Packages: Springer Protocols

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