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Molecular Cytogenetics pp 191–207Cite as

Microarray CGH

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 204))

Abstract

Comparative genomic hybridization (CGH) to metaphase chromosome targets (1,2) has significantly contributed to our understanding of the cancer cytogenetics of more complex malignancies such as solid tumors (3,4). This molecular cytogenetics-based technique (hereafter referred to as “chromosome CGH”) is capable of defining genome-wide DNA copy number imbalances in sample cells relative to a normal reference in a single experiment. Chromosome CGH has greatly increased our understanding of tumor biology and progression since the minimal recurrent regions of chromosomal gain and loss are likely to contain novel oncogene(s) and tumor suppressor gene(s) respectively.

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Author information

Authors and Affiliations

  1. Ontario Cancer Institute, University Health Network, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario, Canada

    Ben Beheshti & Ilan Braude

  2. Ontario Cancer Institute, Department of Laboratory Medicine and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada

    Paul C. Park & Jeremy A. Squire

Authors
  1. Ben Beheshti
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  2. Paul C. Park
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  3. Ilan Braude
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  4. Jeremy A. Squire
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Editor information

Editors and Affiliations

  1. London Health Sciences Center, London

    Yao-Shan Fan

  2. The University of Western Ontario, Ontario, Canada

    Yao-Shan Fan

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© 2002 Humana Press Inc.

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Cite this protocol

Beheshti, B., Park, P.C., Braude, I., Squire, J.A. (2002). Microarray CGH. In: Fan, YS. (eds) Molecular Cytogenetics. Methods in Molecular Biology™, vol 204. Humana Press. https://doi.org/10.1385/1-59259-300-3:191

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  • DOI: https://doi.org/10.1385/1-59259-300-3:191

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-006-9

  • Online ISBN: 978-1-59259-300-2

  • eBook Packages: Springer Protocols

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