Abstract
Conventional nucleic acid/nucleic acid hybridization (1) can be one of the most sensitive procedures for detecting sequence polymorphisms. It forms the basis for many of the diagnostic or screening methods used at present. However, even the most successful of chip-based technologies encounter difficulties in distinguishing between hetero- and homozygous mutational events (2).
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© 2002 Humana Press Inc.
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Igloi, G.L. (2002). Detection of Point Mutations Using PNA-Containing Electrophoresis Matrices. In: Nielsen, P.E. (eds) Peptide Nucleic Acids. Methods in Molecular Biology, vol 208. Springer, Totowa, NJ. https://doi.org/10.1385/1-59259-290-2:195
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DOI: https://doi.org/10.1385/1-59259-290-2:195
Publisher Name: Springer, Totowa, NJ
Print ISBN: 978-0-89603-976-6
Online ISBN: 978-1-59259-290-6
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