Abstract
Mitochondrial DNA is a very vulnerable target for both alkylating and oxidizing agents (1–5). Recent studies from our laboratory demonstrated an association between inefficient mtDNA repair capacity and an increased sensitivity to both types of DNA damaging agent (5–9). To determine if a cell’s sensitivity to a DNA damaging agent can be altered by changing the mtDNA repair capacity, experiments that involve targeting of repair enzymes to mitochondria were undertaken (10). The methods utilized are described in detail within this chapter.
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Dobson, A.W., Kelley, M.R., Wilson, G.L., LeDoux, S.P. (2002). 24 Targeting DNA Repair Proteins to Mitochondria. In: Copeland, W.C. (eds) Mitochondrial DNA. Methods in Molecular Biology™, vol 197. Humana Press. https://doi.org/10.1385/1-59259-284-8:351
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DOI: https://doi.org/10.1385/1-59259-284-8:351
Publisher Name: Humana Press
Print ISBN: 978-0-89603-972-8
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