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Mitochondrial DNA pp 3–54Cite as

Animal Models for Mitochondrial Disease

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 197))

Abstract

Although a variety of degenerative diseases are now known to be caused by two mutations in mitochondrial genes, the pathophysiology of these diseases remains poorly understood. As a consequence, relatively little progress has been made in developing new therapies for mitochondrial diseases. What has been needed are animal models for these diseases that are amenable to detailed biochemical, physiological, and molecular analysis, and on which promising therapies can be tested. In the past 5 yr, this deficiency has begun to be addressed by the construction of a number of mouse models of mitochondrial

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Authors and Affiliations

  1. Center for Molecular Medicine, Emory University School of Medicine, Atlanta, GA

    Douglas C. Wallace

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  1. Douglas C. Wallace
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Editors and Affiliations

  1. Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC

    William C. Copeland

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© 2002 Humana Press Inc.

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Wallace, D.C. (2002). Animal Models for Mitochondrial Disease. In: Copeland, W.C. (eds) Mitochondrial DNA. Methods in Molecular Biology™, vol 197. Humana Press. https://doi.org/10.1385/1-59259-284-8:003

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  • DOI: https://doi.org/10.1385/1-59259-284-8:003

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-972-8

  • Online ISBN: 978-1-59259-284-5

  • eBook Packages: Springer Protocols

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