Abstract
CD4+T cells play an important role in immunity to blood-stage malaria parasites and in disease pathogenesis. The role of CD4+T cells has been demonstrated by selective depletion in vitro (1-3), by adoptive transfer of T cells to immunodeficient mice (1,4-7), and by the ability of human T cells to inhibit parasite growth in vitro (8). Both types of CD4+T cells (Th1 and Th2) have been shown to be effective in malaria infection (6). Factors that affect cell activation, function, and life-span of parasite-specific T cells would be expected to have a significant impact on parasite survival, including the poor immunogenicity of parasite antigens (9), antigenic polymorphism (10-12), immunosuppression as a result of malaria infection (13), and the need for continuous malaria exposure to maintain immunological memory (14). Antigen-driven deletion or anergy of immunological responses is a major regulatory strategy to control potentially harmful responses (15) and may be used by infectious organisms to their advantage, as shown by the exhaustive deletion of lymphocytic choriomeningitis virus-specific CD8+T cells (16), and the deletion of Plasmodium berghei-specific T cells after adoptive transfer into immunodeficient mice (17).
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Hirunpetcharat, C., Good, M.F. (2002). Cell Trafficking. In: Doolan, D.L. (eds) Malaria Methods and Protocols. Methods in Molecular Medicine™, vol 72. Humana Press. https://doi.org/10.1385/1-59259-271-6:401
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DOI: https://doi.org/10.1385/1-59259-271-6:401
Publisher Name: Humana Press
Print ISBN: 978-0-89603-823-3
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