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Assessing CD4+Helper T-Lymphocyte Responses by Lymphoproliferation

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Malaria Methods and Protocols

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 72))

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Abstract

CD4+helper T cells play a central role in the development of malaria immune responses and a large number of epitopes from the sporozoite, sexual, and asexual stage of malaria proteins have been tabulated in both mice and humans (1-8). It is clear that the incorporation of antigenic determinants stimulating helper T cells is important for the induction of antibody responses (9-11) and cytotoxic T cell responses (12-15) stimulated by peptide or subunit vaccines. Helper T cells (Th) also may act as effectors themselves, by secreting cytokines that may significantly influence the clinical course following infection.

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Author information

Authors and Affiliations

  1. Department of Biology, Georgetown University, Washington, DC

    Isabella A. Quakyi

  2. Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD

    Jeffrey D. Ahlers

Authors
  1. Isabella A. Quakyi
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  2. Jeffrey D. Ahlers
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Editor information

Editors and Affiliations

  1. Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA

    Denise L. Doolan

  2. Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD, USA

    Denise L. Doolan

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© 2002 Humana Press Inc.

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Quakyi, I.A., Ahlers, J.D. (2002). Assessing CD4+Helper T-Lymphocyte Responses by Lymphoproliferation. In: Doolan, D.L. (eds) Malaria Methods and Protocols. Methods in Molecular Medicine™, vol 72. Humana Press. https://doi.org/10.1385/1-59259-271-6:369

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  • DOI: https://doi.org/10.1385/1-59259-271-6:369

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-823-3

  • Online ISBN: 978-1-59259-271-5

  • eBook Packages: Springer Protocols

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