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Retinoids in Nonmammalian Embryos

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Molecular Embryology

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 97))

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Abstract

The family of retinoids comprise an enormous number of compounds related to vitamin A. Many of these compounds are naturally occurring substances generated during the biological functioning of retinoids: the conversion of dietary sources of retinoids (β-carotenes, retinyl esters) to those that can be taken up by the absorptive epithelium of the gut (retinol); the conversion of absorbed forms to stored forms in the liver (retinyl esters); the conversion of stored forms to active forms as mediators of vision (retinals), skin differentiation (retinoic acids), and general cell differentiation and proliferation (retinoic acids). However, more of these compounds are synthetic, for example, the retinobenzoic acids, and have been generated in the desire to find more potent and less teratogenic retinoids for pharmaceutical use. This chapter will be concerned only with a very few retinoids, ones that have been used in an embryological context.

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Author information

Authors and Affiliations

  1. Developmental Biology Research Centre, King’s College, London, UK

    Malcolm Maden

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  1. Malcolm Maden
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Editor information

Editors and Affiliations

  1. Dental and Medical Schools of Guy’s, King’s, and St. Thomas’s Hospitals, King’s College, London, UK

    Paul T. Sharpe  & Ivor Mason  & 

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© 1999 Humana Press Inc.

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Maden, M. (1999). Retinoids in Nonmammalian Embryos. In: Sharpe, P.T., Mason, I. (eds) Molecular Embryology. Methods in Molecular Biology™, vol 97. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-270-8:491

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  • DOI: https://doi.org/10.1385/1-59259-270-8:491

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-387-0

  • Online ISBN: 978-1-59259-270-8

  • eBook Packages: Springer Protocols

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