Abstract
Prostaglandin production is dependent on the presence of an enzyme called prostaglandin G/H synthase, better known as cyclooxygenase, that catalyzes the first steps in the conversion from arachidonic acid. A cDNA for cyclooxygenase was first cloned from sheep seminal vesicles in 1988 (1,2). In 1991, we and others reported the cloning of a second isoform of cyclooxygenase, now known as COX-2, that is rapidly induced in response to growth factors and proinflammatory cytokines and downregulated by glucocorticoid hormones (3–6).
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Kerry O’Banion, M., Olschowka, J.A. (1999). Localization and Distribution of Cyclooxygenase-2 in Brain Tissue by Immunohistochemistry. In: Lianos, E.A. (eds) Eicosanoid Protocols. Methods in Molecular Biology, vol 120. Humana Press. https://doi.org/10.1385/1-59259-263-5:55
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DOI: https://doi.org/10.1385/1-59259-263-5:55
Publisher Name: Humana Press
Print ISBN: 978-0-89603-667-3
Online ISBN: 978-1-59259-263-0
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