Abstract
Upon binding to extracellular matrix (ECM) ligands, integrins aggregate on the plane of the plasma membrane and interact on the cytoplasmic side with elements of the cytoskeleton as well as signaling molecules. These events result in the organization of adhesive junctions, such as focal adhesions and hemidesmosomes, and the activation of signaling pathways that regulate gene expression (1,2).
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© 1999 Humana Press Inc.
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Wary, K.K., Dans, M., Mariotti, A., Giancotti, F.G. (1999). Biochemical Analysis of Integrin-Mediated Shc Signaling. In: Howlett, A. (eds) Integrin Protocols. Methods in Molecular Biology, vol 129. Humana Press. https://doi.org/10.1385/1-59259-249-X:35
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DOI: https://doi.org/10.1385/1-59259-249-X:35
Publisher Name: Humana Press
Print ISBN: 978-0-89603-569-0
Online ISBN: 978-1-59259-249-4
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