Abstract
We have found that integrins control apoptosis in epithelial cells, and have named this general phenomenon “anoikis,” the ancient Greek word meaning “homelessness” (1). Epithelial cells that have lost interaction with their extracellular matrix—or that interact with matrix through inappropriate integrin types (2) or other molecules—cannot colonize elsewhere, because of anoikis. This process is developmentally critical, and its loss can contribute significantly to tumor malignancy (reviewed in ref. 3).
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References
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© 1999 Humana Press Inc.
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Frisch, S.M. (1999). Methods for Studying Anoikis. In: Howlett, A. (eds) Integrin Protocols. Methods in Molecular Biology, vol 129. Humana Press. https://doi.org/10.1385/1-59259-249-X:251
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DOI: https://doi.org/10.1385/1-59259-249-X:251
Publisher Name: Humana Press
Print ISBN: 978-0-89603-569-0
Online ISBN: 978-1-59259-249-4
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