Use of cDNA Representational Difference Analysis to Identify Disease-Specific Genes in Human Atherosclerotic Plaques

  • Kerry Tyson
  • Catherine Shanahan
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 30)


Changes in gene expression underlie many biological phenomena, including cellular differentiation and activation, embryonic development, and pathological processes. In recent years, much attention has been focused on the identification of genes that are differentially expressed between normal and disease states: the isolation of disease-specific genes is not only essential for our understanding of the molecular basis of pathological conditions, but may potentially highlight novel therapeutic targets.


Difference Product Polymerase Chain Reaction Machine Mung Bean Nuclease cDNA Representational Difference Analysis Human Atheromatous Plaque 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 1999

Authors and Affiliations

  • Kerry Tyson
    • 1
  • Catherine Shanahan
    • 1
  1. 1.Department of Medicine, Addenbrooke’s HospitalUniversity of CambridgeCambridgeUK

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