Delivery of Recombinant Adenoviruses to Human Saphenous Vein

  • Sarah J. George
  • Andrew H. Baker
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 30)


The human saphenous vein is the most commonly used conduit for coronary artery bypass grafting owing to its ready availability, ease of harvesting, and favorable surgical handling (1). However, it suffers from a progressive decline in patency, resulting in a graft failure rate of 50% after 10 yr (2,3). This high failure rate is caused by either early thrombosis occlusion, which occurs in the first year after graft implantation, or the later development of intimal thickening and superimposed atherosclerosis (1, 2, 3).


Migration Catheter Heparin Penicillin Syringe 


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Copyright information

© Humana Press Inc., Totowa, NJ 1999

Authors and Affiliations

  • Sarah J. George
    • 1
  • Andrew H. Baker
    • 1
  1. 1.Bristol Heart InstituteUniversity of BristolBristolUK

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