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Multiple Tests for Genetic Effects in Association Studies

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Biostatistical Methods

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 184))

Abstract

Many common human diseases have a genetic component as measured by familial studies. Metabolic disorders such as diabetes, cardiovascular diseases such as high blood pressure, psychiatric disorders such as schizophrenia, and neurodegenerative diseases such as Alzheimer’s disease all are thought to have a hereditary component. In some diseases the genetic control is through a single gene, while in others, multiple genes interact in complex ways with environmental factors to produce the disease (1–5).

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Author information

Authors and Affiliations

  1. Department of Mathematics, Keele University, Keele, Staffordshire, UK

    Peter H. Westfall

  2. GlaxoSmithKline, Research Triangle Park, NC

    Dmitri V. Zaykin & S. Stanley Young

Authors
  1. Peter H. Westfall
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  2. Dmitri V. Zaykin
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  3. S. Stanley Young
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Editor information

Editors and Affiliations

  1. University of Louisville School of Medicine, Louisville, Kentucky

    Stephen W. Looney

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© 2002 Humana Press Inc., Totowa, NJ

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Westfall, P.H., Zaykin, D.V., Young, S.S. (2002). Multiple Tests for Genetic Effects in Association Studies. In: Looney, S.W. (eds) Biostatistical Methods. Methods in Molecular Biology™, vol 184. Humana Press. https://doi.org/10.1385/1-59259-242-2:143

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  • DOI: https://doi.org/10.1385/1-59259-242-2:143

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-951-3

  • Online ISBN: 978-1-59259-242-5

  • eBook Packages: Springer Protocols

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