DNA Arrays pp 247-256 | Cite as

Business Aspects of Biochip Technologies

  • Kenneth E. Rubenstein
Part of the Methods in Molecular Biology™ book series (MIMB, volume 170)


In the context of this chapter, biochips are defined as microscale bioanalytical devices that incorporate microfluidic circuitry, highly parallel functionality, or both. Microfluidic circuitry has yielded the lab-on-a-chip concept in which functions such as sample processing, reagent combining, component separation, and detection all occur in sequence on microscale integrated devices. Highly parallel functionality manifests in DNA microarrays, which often contain many thousands of addressable DNA fragments, each capable of hybridizing with a complementary target.


Defense Advance Research Project Agency Defense Advance Research Project Agency Spotted Array Microchannel System Infectious Disease Diagnosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Manz, A., Graber, N., and Widmer, H. M. (1990) Miniaturized total analysis systems: A novel concept for chemical sensors. Sensors Actuators B1, 244–248.CrossRefGoogle Scholar
  2. 2.
    Harrison, D. J., Fluri, K., Seiler, K., Zhonghui, F., Effenhauser, C. S., and Manz, A. (1993) Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip. Science 261, 895–897.PubMedCrossRefGoogle Scholar
  3. 3.
    Jacobson, S. C., Hergenroder, R., Koutny, L. B., and Ramsey, J. M. (1994) High speed separations on a microchip. Analyt. Chem. 66, 1114–1118.CrossRefGoogle Scholar
  4. 4.
    Fodor, S. P. A., Read, J. L., Pirrung, M. C., Stryer, L., Lu, A. T., and Solas, D. (1991) Light-directed spatially addressable parallel chemical synthesis. Science 251, 767–773.PubMedCrossRefGoogle Scholar
  5. 5.
    Cheng, J., Sheldon, E. L., Wu, L., Uribe, A., Gerrue, L. O., Carrino, J., Heller, M. J., and O’Connell, J. P. (1998) Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips. Nat. Biotechnol. 16, 541–546.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2001

Authors and Affiliations

  • Kenneth E. Rubenstein
    • 1
  1. 1.The Lion Consulting GroupEmeryville

Personalised recommendations