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Gel-Immobilized Microarrays of Nucleic Acids and Proteins

Production and Application for Macromolecular Research

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DNA Arrays

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 170))

Abstract

Biochips are small platforms with spatially arrayed macromolecules (or pieces thereof) that allow the collection and analysis of large amounts of biological information. The principle of the technology is based on specific molecular recognition interactions between the arrayed macromolecules and the test molecule of interest. Classical examples of such recognition reactions are the interactions between the two complementary strands of a double-helical DNA molecule, between a single-stranded DNA stretch and the messenger RNA copied from it during transcription, between an antigen and an antibody, and between small ligands and their nucleic acid or protein partners.

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Author information

Authors and Affiliations

  1. Biochip Technology Center, Argonne National Laboratory, Argonne, IL

    Jordanka Zlatanova & Andrei Mirzabekov

  2. Joint Human Genome Project, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

    Andrei Mirzabekov

Authors
  1. Jordanka Zlatanova
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  2. Andrei Mirzabekov
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Editor information

Editors and Affiliations

  1. Beckman Coulter, Inc., Fullerton, CA

    Jang B. Rampal

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© 2001 Humana Press Inc.

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Zlatanova, J., Mirzabekov, A. (2001). Gel-Immobilized Microarrays of Nucleic Acids and Proteins. In: Rampal, J.B. (eds) DNA Arrays. Methods in Molecular Biology™, vol 170. Humana Press. https://doi.org/10.1385/1-59259-234-1:17

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  • DOI: https://doi.org/10.1385/1-59259-234-1:17

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-822-6

  • Online ISBN: 978-1-59259-234-0

  • eBook Packages: Springer Protocols

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