Optical Biosensor Techniques to Analyze Protein-Polysaccharide Interactions
Networks of interacting molecules, operating from the outside of the cell to the cell nucleus, regulate cell behavior. Optical biosensors provide a means of analyzing these interactions and possess key advantages over other methods: posttranslationally modified proteins, secondary gene products such as polysaccharides, chemically synthesized molecules, and nucleic acids are all equally susceptible to analysis; a quantitative description of an interaction is obtained; the structural rules and the kinetics governing the formation of multimolecular assemblies can be probed.
KeywordsHeparin Polysaccharide Carboxyl Immobilization Thiol
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