Abstract
This chapter outlines methods to estimate, through calculation and modeling, a major destabilizing contributor to protein stability—conformational entropy. This is not a comprehensive review of all published calculations of conformational entropy, but rather serves as a guide for those interested in performing such calculations. The methods outlined in this chapter provide an opportunity to estimate some of the entropic contributions to protein stability. Such methods are currently limited to estimating conformational entropy for relatively small parts of proteins, such as side chains or small pep-tides. Yet these calculations can provide much insight into the role of conformational entropy in protein stability.
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Creamer, T.P. (2001). Conformational Entropy in Protein Folding. In: Murphy, K.P. (eds) Protein Structure, Stability, and Folding. Methods in Molecular Biology™, vol 168. Humana Press. https://doi.org/10.1385/1-59259-193-0:117
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DOI: https://doi.org/10.1385/1-59259-193-0:117
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