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Natural Animal Models of Human Genetic Diseases

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Cystic Fibrosis Methods and Protocols

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 70))

Abstract

The earth’s organisms are a vast repository of genetic diversity. Each species (n>106) is distinguished from every other by a unique genomic sequence that is passed on to successive generations with extremely high, but not perfect, fidelity. Imperfections in DNA replication and repair mean that the genome of each member of a species is also unique. Intraspecific differences are one basis for individuality, including individual differences in susceptibility to disease. The most striking example of such differences is genetic diseases.

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Author information

Authors and Affiliations

  1. Cystic Fibrosis Research Laboratory, Stanford University, Stanford, CA

    Jeffrey J. Wine

  2. Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD

    Michael Dean

  3. Laboratory of Molecular Pathology, University of Ljubljana, Ljubljana, Slovenia

    Damjan Glavac

Authors
  1. Jeffrey J. Wine
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  2. Michael Dean
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  3. Damjan Glavac
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Editor information

Editors and Affiliations

  1. Division of Molecular Medicine, Oregon Health Sciences University, Portland, OR

    William R. Skach MD

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© 2002 Humana Press Inc.

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Wine, J.J., Dean, M., Glavac, D. (2002). Natural Animal Models of Human Genetic Diseases. In: Skach, W.R. (eds) Cystic Fibrosis Methods and Protocols. Methods in Molecular Medicine™, vol 70. Humana Press. https://doi.org/10.1385/1-59259-187-6:31

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  • DOI: https://doi.org/10.1385/1-59259-187-6:31

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-897-4

  • Online ISBN: 978-1-59259-187-9

  • eBook Packages: Springer Protocols

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