Advertisement

Murine Models of CF Airway Infection and Inflammation

  • James F. Chmiel
  • Michael W. Konstan
  • Melvin Berger
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 70)

Keywords

Cystic Fibrosis Cystic Fibrosis Patient Agarose Bead Blood Agar Plate Monitor Screen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Cash, H. A., Woods, D. E., McCullough, B., Johanson, W. G., Jr., and Bass, J. A. (1979) A rat model of chronic respiratory infection with Pseudomonas aeruginosa. Am. Rev. Respir. Dis. 119, 453–459.Google Scholar
  2. 2.
    Davis, P. B., Drumm, M., and Konstan, M. W. (1996) Cystic fibrosis: State of the art. Am. J. Respir. Crit. Care Med. 154, 1229–1256.PubMedGoogle Scholar
  3. 3.
    Hancock, R. E. W., Mutharia, L. M., Chan, L., Darveau, R. P., Speert, D. P., and Pier, G. B. (1983) Pseudomonas aeruginosa isolates from patients with cystic fibrosis: A class of serum sensitive, nontypable strains deficient in lipopolysaccharide O side chains. Infect. Immunol. 42, 170–177.Google Scholar
  4. 4.
    Konstan, M. W. and Berger, M. (1993) Infection and inflammation in the lung in cystic fibrosis, in Cystic Fibrosis (Davis, P. B., ed.), MarcelDekker, New York, NY, pp. 219–276.Google Scholar
  5. 5.
    Konstan, M. W. and Berger, M. (1997) Current understanding of the inflammatory process in cystic fibrosis: Onset and etiology. Pediatr. Pulmonol. 24, 137–142.CrossRefPubMedGoogle Scholar
  6. 6.
    Winnie, G. B., Klinger, J. D., Sherman, J. M., and Thomassen, M. J. (1982) Induction of phagocytic inhibitory activity in cats with chronic Pseudomonas aeruginosa pulmonary infection. Infect. Immun. 38, 1088–1093.PubMedGoogle Scholar
  7. 7.
    Pennington, J. E., Hickey, W. F., and Blackwood, L. L. (1981) Active immunization with lipopolysaccharide pseudomonas antigen for chronic pseudomonas bron-chopneumonia in guinea pigs. J. Clin. Invest. 68, 1140–1148.CrossRefGoogle Scholar
  8. 8.
    Chung, A. T., Moss, R. B., Leong, A. B., and Novick, W. J., Jr. (1992) Chronic Pseudomonas aeruginosa endobronchitis in rhesus monkeys: I. Effects of pentoxyfylline on neutrophil influx. J Med. Primatol. 21, 357–362.Google Scholar
  9. 9.
    Starke, J. R., Edwards, M. S., Langston, C., and Baker, C. J. (1987) A mouse model of chronic pulmonary infection with Pseudomonas aeruginosa and Pseudomonas cepacia. Pediatr. Res. 22, 698–702.Google Scholar
  10. 10.
    van Heeckeren, A., Walenga, R., Konstan, M. W., Bonfield, T., Davis, P. B., and Ferkol, T. (1997) Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa. J. Clin. Invest. 100, 2810–2815.CrossRefGoogle Scholar
  11. 11.
    Woods, D. E., Sokol, P. A., Bryan, L. E., Storey, D. G., Mattingly, S. J., Vogel, H. J., and Ceri, H. (1991) In vivo regulation of virulence in Pseudomonas aeruginosa associated with genetic rearrangement. J. Infect. Dis. 163, 143–149.Google Scholar
  12. 12.
    Konstan, M. W., Vargo, K. M., and Davis, P. B. (1990) Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection: Implications for antiinflammatory therapy in cystic fibrosis. Am. Rev. Respir. Dis. 141, 186–192.PubMedGoogle Scholar
  13. 13.
    Konstan, M. W., Byard, P. J., Hoppel, C. L., and Davis, P. B. (1995) Effect of highdose ibuprofen in patients with cystic fibrosis. N. Engl. J. Med. 332, 848–854.CrossRefPubMedGoogle Scholar
  14. 14.
    Chmiel, J. F., Konstan, M. W., Knesebeck, J. E., Hilliard, J. B., Bonfield, T. L., Dawson, D. V., and Berger, M. (1999) IL-10 attenuates excessive inflammation in chronic pseudomonas infection in mice. Am. J. Respir. Crit. Care Med. 160, 2040–2047.PubMedGoogle Scholar
  15. 15.
    Yu, H., Hanes, H., Chrisp, C. E., Boucher, J. C., and Dretic, V. (1998) Microbial pathogenesis in cystic fibrosis: Pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge. Infect. Immun. 66, 280–288.PubMedGoogle Scholar
  16. 16.
    Morissette, C., Skamene, E., and Gervais, F. (1995) Endobronchial inflammation following Pseudomonas aeruginosa infection in resistant and susceptible strains of mice. Infect. Immun. 63, 1718–1724.PubMedGoogle Scholar
  17. 17.
    Sapru, K., Stotland, P. K., and Stevenson, M. M. (1999) Quantitative and qualitative differences in bronchoalveolar inflammatory cells in Pseudomonas aeruginosa-resis- tant and susceptible strains of mice. Clin. Exp. Immunol. 115, 103–109.CrossRefPubMedGoogle Scholar
  18. 18.
    Tam, M., Snipes, G. J., and Stevenson, M. M. (1999) Characterization of chronic bronchopulmonary Pseudomonas aeruginosa infection in resistant and susceptible inbred mouse strains. Am. J. Respir. Cell Mol. Biol. 20, 710–719.PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • James F. Chmiel
    • 1
  • Michael W. Konstan
    • 1
  • Melvin Berger
    • 1
  1. 1.Department of PediatricsRainbow Babies and Children’s Hospital and Case Western Reserve University School of MedicineCleveland

Personalised recommendations