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Routes of Stem Cell Administration in the Adult Rodent

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Neural Stem Cells: Methods and Protocols

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 198))

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Abstract

Arguably one of the most exciting developments in science in the last decade is the discovery and isolation of neural stem cells (NSCs), not only from the embryonic (1,2) but also from the adult human brain (3,4). With the ability of a NSC to proliferate, self-renew, and generate a large number of clonally related progeny of a neuronal, astrocytic, or oligodendrocytic lineage, these cells promise to revolutionize the treatment of neurological disease. The potential of these cells to correct genetic diseases, such as those resulting from inborn errors of metabolism, is staggering. Studies in myelin-deficient rat (5) and shiverer mouse (6) demonstrated that it is possible to correct a myelin deficiency.

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Author information

Authors and Affiliations

  1. Center for Aging and Brain Repair, Departments of Neurosurgery and Anatomy, College of Medicine, University of South Florida, Tampa, FL

    Alison E. Willing & Samuel Saporta

  2. Center for Aging and Brain Repair, Department of Neurosurgery, College of Medicine, University of South Florida, Tampa, FL

    Svitlana Garbuzova-Davis

  3. Departments of Neurosurgery, Psychiatry, Psychology, Pharmacology and Center for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, FL

    Paul R. Sanberg

Authors
  1. Alison E. Willing
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  2. Svitlana Garbuzova-Davis
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  3. Paul R. Sanberg
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  4. Samuel Saporta
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of South Florida College of Medicine, Tampa, FL

    Tanja Zigova PhD , Paul R. Sanberg PhD, DSc  & Juan R. Sanchez-Ramos PhD, MD ,  & 

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© 2002 Humana Press Inc.

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Willing, A.E., Garbuzova-Davis, S., Sanberg, P.R., Saporta, S. (2002). Routes of Stem Cell Administration in the Adult Rodent. In: Zigova, T., Sanberg, P.R., Sanchez-Ramos, J.R. (eds) Neural Stem Cells: Methods and Protocols. Methods in Molecular Biology™, vol 198. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-186-8:357

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  • DOI: https://doi.org/10.1385/1-59259-186-8:357

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-964-3

  • Online ISBN: 978-1-59259-186-2

  • eBook Packages: Springer Protocols

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