Routes of Stem Cell Administration in the Adult Rodent

  • Alison E. Willing
  • Svitlana Garbuzova-Davis
  • Paul R. Sanberg
  • Samuel Saporta
Part of the Methods in Molecular Biology™ book series (MIMB, volume 198)


Arguably one of the most exciting developments in science in the last decade is the discovery and isolation of neural stem cells (NSCs), not only from the embryonic (1,2) but also from the adult human brain (3,4). With the ability of a NSC to proliferate, self-renew, and generate a large number of clonally related progeny of a neuronal, astrocytic, or oligodendrocytic lineage, these cells promise to revolutionize the treatment of neurological disease. The potential of these cells to correct genetic diseases, such as those resulting from inborn errors of metabolism, is staggering. Studies in myelin-deficient rat (5) and shiverer mouse (6) demonstrated that it is possible to correct a myelin deficiency.


Neural Stem Cell Middle Cerebral Artery Occlusion Tail Vein External Carotid Bone Flap 
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Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Alison E. Willing
    • 1
  • Svitlana Garbuzova-Davis
    • 2
  • Paul R. Sanberg
    • 3
  • Samuel Saporta
    • 1
  1. 1.Center for Aging and Brain Repair, Departments of Neurosurgery and Anatomy, College of MedicineUniversity of South FloridaTampa
  2. 2.Center for Aging and Brain Repair, Department of Neurosurgery, College of MedicineUniversity of South FloridaTampa
  3. 3.Departments of Neurosurgery, Psychiatry, Psychology, Pharmacology and Center for Aging and Brain RepairCollege of Medicine, University of South FloridaTampa

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