Abstract
The ability of neurons to communicate with each other lies at the center of brain function. Communication between neurons occurs primarily by synaptic transmission and is mediated by neurotransmitters that are released by synaptic vesicle exocytosis. This process is tightly regulated by a complex protein machinery and is triggered by Ca2+influx into a presynaptic terminal when an action potential causes opening of voltage-gated Ca2+-channels (1). The synaptic vesicle protein synaptotagmin I is an essential component of this machinery (2), acting most likely as a Ca2+sensor in neurotransmitter release (3). The Ca2+-binding properties of synaptotagmin I are thus likely to be key for the mechanism of interneuronal communication.
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Rizo, J., Ubach, J., GarcÍa, J. (2002). Ca2+-Binding Mode of the C2A-Domain of Synaptotagmin. In: Vogel, H.J. (eds) Calcium-Binding Protein Protocols. Methods in Molecular Biology™, vol 172. Humana Press. https://doi.org/10.1385/1-59259-183-3:305
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DOI: https://doi.org/10.1385/1-59259-183-3:305
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