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Linkage and Association

The Transmission/Disequilibrium Test for QTLs

  • Protocol
Quantitative Trait Loci

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 195))

Abstract

Usually, the probability of observing a particular allele at one locus is independent of the alleles observed at another locus. However, this is not the case when two alleles are ‘associated.’ For instance, let the frequency of allele 1 at locus 1 by p 1 and the frequency of allele 2 at locus 2 be p 2 . If the two alleles are not associated, then the frequency with which they appear together is p 1 p 2 . If their joint frequency is greater than p 1 p 2 the two alleles are said to be positively associated. If their joint frequency is less than p 1 p 2 , the two alleles are said to be negatively associated. Association is the nonindependence of allele frequencies at different loci.

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Author information

Authors and Affiliations

  1. Division of Genomic Medicine, University of Sheffield, UK

    Mark M. Iles

Authors
  1. Mark M. Iles
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Editor information

Editors and Affiliations

  1. Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, UT

    Nicola J. Camp

  2. Institute for Cancer Studies, University of Sheffield Medical School, Sheffield, UK

    Angela Cox

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© 2002 Humana Press Inc.

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Iles, M.M. (2002). Linkage and Association. In: Camp, N.J., Cox, A. (eds) Quantitative Trait Loci. Methods in Molecular Biology™, vol 195. Humana Press. https://doi.org/10.1385/1-59259-176-0:101

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  • DOI: https://doi.org/10.1385/1-59259-176-0:101

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-927-8

  • Online ISBN: 978-1-59259-176-3

  • eBook Packages: Springer Protocols

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