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Lipids in Viral Fusion

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Book cover Liposome Methods and Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 199))

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Abstract

Enveloped animal viruses infect host cells by fusion of viral and target membranes. This crucial fusion event occurs either with the plasma membrane of the host cells or with the endosomal membranes (1). Fusion is triggered by specific glycoproteins in the virus membrane (2) and involves a range of steps before the final merging of membranes occurs. These steps include molecular processes, such as envelope protein conformational changes; aggregation of envelope protein; lipid-envelope protein interactions; and fusion pore formation and pore widening (see Fig. 1) (3,4). The reader is referred to a number of reviews on viral glycoprotein-mediated membrane fusion (5–9).

A cartoon depicting various fusion intermediates following structural changes in viral proteins. This cartoon taken from Blumenthal et al. (3) shows fusion intermediates after virus binds to the target cells.

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Author information

Authors and Affiliations

  1. Labratory of Experimental and Computational Biology, NCI-FCRDC, Frederick, MD

    Anu Puri & Robert Blumenthal

  2. UMR 8612, Université Paris Sud, Chatenay-Malabry, France

    Maite Paternostre

Authors
  1. Anu Puri
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  2. Maite Paternostre
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  3. Robert Blumenthal
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Editor information

Editors and Affiliations

  1. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN

    Subhash C. Basu  & Manju Basu  & 

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© 2002 Humana Press Inc.

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Puri, A., Paternostre, M., Blumenthal, R. (2002). Lipids in Viral Fusion. In: Basu, S.C., Basu, M. (eds) Liposome Methods and Protocols. Methods in Molecular Biology, vol 199. Humana Press. https://doi.org/10.1385/1-59259-175-2:61

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  • DOI: https://doi.org/10.1385/1-59259-175-2:61

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-845-5

  • Online ISBN: 978-1-59259-175-6

  • eBook Packages: Springer Protocols

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