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The v-erbA Oncogene

Assessing Its Differentiation-Blocking Ability Using Normal Chicken Erythrocytic Progenitor Cells
  • Olivier Gandrillon
Part of the Methods in Molecular Biology book series (MIMB, volume 202)

Abstract

The v-erbA oncogene is the most clear-cut case of an oncogene that acts by blocking a differentiation sequence (for a review, see ref. 1). It has been discovered as one of the two oncogenes carried by the avian erythroblastosis virus (AEV), a leukemia-inducing retrovirus. It is derived from the c-erbA protooncogene, which encodes the α form of the nuclear receptor for the thyroid hormone triiodothyronine (T3Rα) (2,3); for a detailed description of the structural differences between v-erbA and T3Rα, see ref. 4). Thyroid hormone receptors belong to the large superfamily of structurally and functionally related receptors that includes the receptors for thyroid hormone (T3R), retinoic acid (either all-trans or 9-cis isoforms, RARs and RXRs) and vitamin D3 (VD3R), which are all lipophilic ligand-regulated transcription factors (5).

Keywords

Viral Stock Butyl Rubber Stopper Human Recombinant Protein Differentiation Blockade Dominant Negative Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Olivier Gandrillon
    • 1
  1. 1.Signalisations et Identités Cellulaires, Centre de Génétique Moléculaire et CellulaireUMR CNRS, Université Claude Bernard Lyon IVilleurbanne CedexFrance

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