Abstract
Invasive disease caused by Neisseria meningitidis is one of the leading infectious causes of death in childhood in North America (1), but its prevention has not received the same priority on the health agenda as in Europe, Australia, and New Zealand. There are several likely explanations, but the principal one is that disease incidence appears to be lower in both Canada (2) and the United States (3) than in some of these other countries (4,5). Here, we describe recent epidemiological data concerning meningococcal infection in Canada and the United States and comment on the possible future introduction of vaccination to prevent meningococcal disease across the continent.
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Hoyert D. L., Kochaneck K. D., and Murpht S. L. (1999) Deaths: Final Data for 1997, National Vital Statistics Reports vol. 47. Centers for Disease Control and Prevention, Atlanta, GA, pp. 55–57.
Deeks S., Kertesz D., Ryan A., Johnson W., and Ashton F. (1997) Surveillance of invasive meningococcal disease in Canada, 1995-1996. Can. Commun. Dis. Rep. 23, 121–125.
Rosenstein N. E., Perkins B. A., Stephens D. S., Lefkowitz L., Cartter M. L., Danila R., et al. (1999) The changing epidemiology of meningococcal disease in the United States, 1992-1996. J. Infect. Dis. 180, 1894–1901.
Noah N. and Conolly M. (1996) Surveillance of Bacterial Meningitis in Europe 1995. King’ European Meningitis Surveillance Unit, London, UK.
Kieft C., Martin D., and Baker M. (2000) The Epidemiology of Meningococcal Disease in New Zealand in 1999. Ministry of Health, Wellington, New Zealand, Wellington, pp. 1–39.
Caugant D. A., Høiby E. A., Magnus P., Scheel O., Hoel T., Bjune G., et al. (1994) Asymptomatic carriage of Neisseria meningitidis in a randomly sampled population. J. Clin. Microbiol. 32, 323–330.
Davis B. D., Dulbecco R., Eisen H. N., and Ginsberg H. S. (1980) The Neisseriae, in Microbiology (Gotschlich E. C., ed.), Harper, New York, NY, pp. 635–644.
Achtman M. (1995) Global epidemiology of meningococcal disease, in Meningococcal Disease (Cartwright K. A. V., ed.), John Wiley and Sons, Chichester, UK, pp. 159–175.
Centers for Disease Control and Prevention (2000) Neisseria meningitidis. Active bacterial core surveillance reports. http://www.cdc.gov/ncidod/dbmd/abcs.
Centers for Disease Control and Prevention (1997) Case definitions for infectious conditions under public health surveillance. Morb. Mortal. Wkly Rep. 46, 1–55.
Varughese P. V. (1989) Meningococcal disease in Canada: surveillance summary to 1987. CMAJ 141, 567–569.
Centers for Disease Control and Prevention (1999) Notifiable diseases: Summary of reported cases per 100,000 population, United States. Morb. Mortal. Wkly Rep. 47, 77–83.
Centers for Disease Control and Prevention (1993) Summary of notifiable diseases, United States, 1993. Morb. Mortal. Wkly Rep. 42, 1–73.
Moore P. S., Hierholzer J., De Witt W., Gouan K., Djore D., Lippeveld T., et al. (1990) Respiratory viruses and mycoplasma as cofactors for epidemic group A meningococcal meningitis. JAMA 264, 1271–1275.
Cartwright K. A., Jones D. M., Smith A. J., Stuart J. M., Kaczmarski E. B., and Palmer S. R. (1991) Influenza A and meningococcal disease. Lancet 338, 554–557.
Stanwell-Smith R. E., Stuart J. M., Hughes A. O., Robinson P., Griffin M. B., and Cartwright K. (1994) Smoking, the environment and meningococcal disease: a case control study. Epidemiol. Infect. 112, 315–328.
Fischer M., Hedberg K., Cardosi P., Plikaytis B. D., Hoesly F. C., Steingart K. R., et al. (1997) Tobacco smoke as a risk factor for meningococcal disease. Pediatr. Infect. Dis. J. 16, 979–983.
Haneberg B., Tonjum T., Rodahl K., and Gedde-Dahl T. W. (1983) Factors preceding the onset of meningococcal disease, with special emphasis on passive smoking, symptoms of ill health. NIPH Ann. 6, 169–173.
Yusuf H. R., Rochat R. W., Baughman W. S., Gargiullo P. M., Perkins B. A., Brantley M. D., and Stephens D. S. (1999) Maternal cigarette smoking and invasive meningococcal disease: a cohort study among young children in metropolitan Atlanta, 1989–1996. Am. J. Public Health 89, 712–717.
Imrey P. B., Jackson L. A., Ludwinski P. H., England A. C., 3rd, Fella G. A., Fox B. C., et al. (1995) Meningococcal carriage, alcohol consumption, and campus bar patronage in a serogroup C meningococcal disease outbreak. J. Clin. Micriobiol. 33, 3133–3137.
Imrey P. B., Jackson L. A., Ludwinski P. H., England A. C., 3rd, Fella G. A., Fox B. C., et al. (1996) Outbreak of serogroup C meningococcal disease associated with campus bar patronage. Am. J. Epidemiol. 143, 624–630.
Cookson S. T., Corrales J. L., Lotero J. O., Regueira M., Binsztein N., Reeves M. W., et al. (1998) Disco fever: epidemic meningococcal disease in northeastern Argentina associated with disco patronage. J. Infect. Dis. 178, 266–269.
Petersen B. H., Lee T. J., Snyderman R., and Brooks G. F. (1979) Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency. Ann. Intern. Med. 90, 917–920.
Figueroa J., Andreoni J., and Densen P. (1993) Complement deficiency states and meningococcal disease. Immunol. Res. 12, 295–311.
Salit I. E. (1981) Meningococcemia caused by serogroup W135. Association with hypogammaglobulinemia. Arch. Intern. Med. 141, 664–665.
Hobbs J. R., Milner R. D., and Watt P. J. (1967) Gamma-M deficiency predisposing to meningococcal septicaemia. BMJ 4, 583–586.
Ellison E. C. and Fabri P. J. (1983) Complications of splenectomy. Etiology, prevention and management. Surg. Clin. North Am. 63, 1313–1330.
Fischer M., Harrison L., Farley M., et al. (1998) Risk Factors for Sporadic Men-ingococcal Disease in North America. Infectious Diseases Society of America, Denver, Colorado, p. 180.
Mitchell S. R., Nguyen P. Q., and Katz P. (1990) increased risk of neisserial infections in systemic lupus erythematosus. Semin. Arthritis Rheum. 20, 174–184.
Stephens D. S., Hajjeh R. A., Baughman W. S., Harvey R. C., Wenger J. D., and Farley M. M. (1995) Sporadic meningococcal disease in adults: results of a 5-year population-based study. Ann. Intern. Med. 123, 937–940.
Jackson L. A. and Wenger J. D. (1993) Laboratory-based surveillance for meningococcal disease in selected areas, United States, 1989–1991. Morb. Mortal. Wkly Rep. CDC Surveill. Summ. 42, 21–30.
Kirsch E. A., Barton R. P., Kitchen L., and Giroir B. P. (1996) Pathophysiology, treatment and outcome of meningococcemia: areview andrecent experience. Pediatr. Infect. Dis. J. 15, 967–978.
Edwards M. S. and Baker C. J. (1981) Complications and sequelae of meningococcal infections in children. J. Pediatr. 99, 540–545.
Jackson L. A., Schuchat A., Reeves M. W., and Wenger J. D. (1995) Serogroup C meningococcal outbreaks in the United States. An emerging threat. JAMA 273, 383–389.
Woods C. R., Rosenstein N., and Perkins B. A. (1998) Neisseria meningitidis Outbreaks in the United States, 1994–1997. Denver, CO, p. 125FR.
Centers for Disease Control and Prevention (1997) Control and prevention of serogroup C meningococcal disease: evaluation and management of suspected outbreaks: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb. Mortal. Wkly Rep. 46, 13–21.
Diermayer M., Hedberg K., Hoesly F., Fischer M., Perkins B., Reeves M., and Fleming D. (1999) Epidemic serogroup B meningococcal disease in Oregon: the evolving epidemiology of the ET-5 strain. JAMA 281, 1493–1497.
Sullivan A., Hedberg K., Reeves M., et al. (2000) Natural history of epidemic serogroup B meningococcal disease, Oregon 1998 and 1999. Atlanta, GA, p. 143.
Ashton F. E., Ryan J. A., Borczyk A., Caugant D. A., Mancino L., and Huang D. (1991) Emergence of a virulent clone of Neisseria meningitidis serotype 2a that is associated with meningococcal group C disease in Canada. J. Clin. Microbiol. 29, 2489–2493.
Whalen C. M., Hockin J. C., Ryan A., and Ashton F. (1995) The changing epidemiology of invasive meningococcal disease in Canada, 1985 through 1992. Emergence of a virulent clone of Neisseria meningitidis. JAMA 273, 390–394.
Woods C. R., Rosenstein N., and Perkins B. A. (1998) Neisseria meningitidis Outbreaks in the United States 1994–97, Denver, CO, p. 125FR.
Varughese P. and Acres S. (1983) Meningococcal disesae in Canada and serogroup distribution. Can. Dis. Wkly Rep. 9, 177–180.
Squires S. G., Pelletier L., Mungai M., Tsang R., Collins F., and Stoltz J. (2000) Invasive meningococcal disease in Canada, 1 January 1997 to 31 December 1998. CCDR 26–21, 177–182.
Centers for Disease Control and Prevention (2000) Serogroup W-135 meningococcal disease among travelers returning from Saudi Arabia—United States, 2000. MMWR Morb. Mortal. Wkly Rep. 49, 345–346.
Rosenstein N., Levine O., Taylor J. P., Evans D., Plikaytis B. D., Wenger J. D., and Perkins B. A. (1998) Efficacy of meningococcal vaccine and barriers to vaccination. JAMA 279, 435–439.
MacLennan J., Obaro S., Deeks J., Williams D., Pais L., Carlone G., et al. (1999) Immune response to re vaccination with meningococcal A and C polysac-charides in Gambian children following repeated immunisation during early childhood. Vaccine 17, 3086–3093.
Immunization N.A.C.O. (1998) Meningococcal vaccine, in Canadian Immunization Guide Fifth Edition, 1998 (Scheifele D., ed.), Canadian Medical Association, Ottawa, pp. 125–129.
Birk H. (1999) An Advisory Committee Statement (ACS). Committee to Advise on Tropical Medicine and Travel (CATMAT). Statement on meningococcal vaccination for travellers. Can. Commun. Dis. Rep. 25, 1–12.
Centers for Disease Control and Prevention (1999) Change in recommendation for meningococcal vaccine for travelers. MMWR Morb. Mortal. Wkly Rep. 48, 104.
Center for Disease Control and Prevention (1997) Health Information for International Travel 1996–1997. U.S. Department of Health and Human Services, Atlanta, GA.
Harrison L. H., Dwyer D. M., Maples C. T., and Billmann L. (1999) Risk of meningococcal infection in college students. JAMA 281, 1906–1910.
Jackson L. A., Schuchat A., Gorsky R. D., and Wenger J. D. (1995) Should college students be vaccinated against meningococcal disease? A cost-benefit analysis. Am. J. Public Health 85, 843–845.
Pollard A. J., Bigham J. M., Bhachu K., Shaw C., Isaac-Renton J., Tan R., and Thomas E. (2001) Meningococcal disease in British Columbia. Br. Columb. Med. J. 43, 9–15.
McDougal L. K., Rasheed J. K., Biddle J. W., and Tenover F. C. (1995) Identification of multiple clones of extended-spectrum cephalosporin-resistant Streptococcus pneumoniae isolates in the United States. Antimicrob. Agents Chemother. 39, 2282–2288.
Scheifele D., Halperin S., Pelletier L., and Talbot J. (2000) Invasive pneumo-coccal infections in Canadian children, 1991–1998: implications for new vaccination strategies. Clin. Infect. Dis. 31, 58–64.
Black S., Shinefield H., Fireman B., Lewis E., Ray P., Hansen R. J., et al. (2000) Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group [see comments]. Pediatr. Infect. Dis. J. 19, 187–195.
Advisory Committee on Immunization Practices Vaccines for Children Programme (2000) Pneumococcal. http://www.cdc.gov/nip/vfc/acip.htm Resolution No. 6/00-1.
Perkins B. A. (2000) New opportunities for prevention of meningococcal disease. JAMA 283, 2842–2843.
Booy R., Hodgson S., Carpenter L., Mayon-White R. T., Slack M. P. E., Macfarlane J. A., et al. (1994) Efficacy of Heamophilus influenzae type b conjugate vaccine PRP-T. Lancet 344, 362–366.
Maiden M. C. and Spratt B. G. (1999) Meningococcal conjugate vaccines: new opportunities and new challenges. Lancet 354, 615–616.
Wyle F. A., Artenstein M. S., Brandt B. L., Tramont E. C., Kasper D. L., Altieri P. L., et al. (1972) Immunologic response of man to group B meningococcal polysaccharide vaccines. J. Infect. Dis. 126, 514–521.
Pollard A. J. and Levin M. (2000) Vaccines for prevention of meningococcal disease. Pediatr. Infect. Dis. J. 19, 333–345.
Tondella M. L., Popovic T., Rosenstein N. E., Lake D. B., Carlone G. M., Mayer L. W., and Perkins B. A. (2000) Distribution of Neisseria meningitidis serogroup B serosubtypes and serotypes circulating in the united states. J. Clin. Microbiol. 38, 3323–3328.
Sacchi C. T., Whitney A. M., Popovic T., Beall D. S., Reeves M. W., Plikaytis B. D., et al. (2000) Diversity and prevalence of PorA types in Neisseria meningitidis serogroup B in the united states, 1992–1998. J. Infect. Dis. 182, 1169–1176.
Parkhill J., Achtman M., James K. D., Bentley S. D., Churcher C., Klee S. R., et al. (2000) Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491 [see comments]. Nature 404, 502–506.
Tettelin H., Saunders N. J., Heidelberg J., Jeffries A. C., Nelson K. E., Eisen J. A., et al. (2000) Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science 287, 1809–1815.
Perkins B. A. (1999) In James W. E. (ed.) Public Health Perspective on Menin-gococcal Disease in the US. Postgraduate Institute for Medicine, Englewood, CO, pp. 3–6.
Varughese P. V. and Carter A. O. (1989) Meningococcal disease in Canada. Surveillance summary to 1987. Can. Dis. Wkly. Rep. 15, 89–96.
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Pollard, A.J., Scheifele, D., Rosenstein, N. (2001). Epidemiology of Meningococcal Disease in North America. In: Walker, J.M., Pollard, A.J., Maiden, M.C.J. (eds) Meningococcal Disease. Methods in Molecular Medicine™, vol 67. Humana Press. https://doi.org/10.1385/1-59259-149-3:341
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DOI: https://doi.org/10.1385/1-59259-149-3:341
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