Abstract
Successful pathogens have evolved a variety of specific gene products that facilitate their survival and growth within the host, as well as mechanisms to regulate expression of these virulence-associated genes in response to their environment. In comparison with commensals, the pathogenic phenotype can thus be seen as a consequence of both differences in gene content and gene expression. Not surprisingly, identification of these differences is a frequent goal in modern biomedical research, and as a result, a variety of differential screening methods have been developed over the last few years (1,2).
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© 2001 Humana Press Inc., Totowa, NJ
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Bowler, L.D., Bart, A., van der Ende, A. (2001). Representational Difference Analysis. In: Walker, J.M., Pollard, A.J., Maiden, M.C.J. (eds) Meningococcal Disease. Methods in Molecular Medicine™, vol 67. Humana Press. https://doi.org/10.1385/1-59259-149-3:231
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DOI: https://doi.org/10.1385/1-59259-149-3:231
Publisher Name: Humana Press
Print ISBN: 978-0-89603-849-3
Online ISBN: 978-1-59259-149-7
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